69. Variants of preoperative thermoradiotherapy in locally advanced breast cancer patients

Abstract

To improve treatment results of locally advanced breast cancer 60 patients with T3-4N1-2M0 TNM stage were undergone complex treatment at the Dept. of Radiotherapy of the CRC. The treatment complex included: radio- or thermoradiotherapy and polychemiohormone-therapy. All patients were subdivided into 3 groups. The first group of 20 patients received radiotherapy only, the second one (18 patients) – thermoradiotherapy, and the third group of 22 patients – thermoradoitherapy plus additional local irradiation of the primary and/or big lymphnode metastases. Radiotherapy was with 2 Gy fractions 5 times per week to the primary tumor and lymphcollectors. Total dose was 40–50 Gy. Results of the therapy were evaluated after 3–4 weeks and the patients were received a surgery. The second group of the patients received local hypertherima after 2 weeks of conventional treatment. Primary tumor and big metastatic nodes were heated. Hyperthermia was performed 2 times per week, with duration of 60 minutes, 3 hours after irradiation. Temperature in tumor was 43–45 C. In the third group of patients additional boost to tumor and/or big metastatic nodes was performed with 2 Gy fractions. Total doses were the same as in first and second group, local tumor dose was 64–72 Gy. Complete or partial regression was more frequently registered in first and second group (39%, 62% respectively). In first group rate was 2%. Rate of postirradiation pathomorphosis of 3–4 grade was 35% in first group, 50% in second, 66% in third group. This data shows improvement of nearest treatment results.