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Vol 6, No 1 (2001)
Untitled
Published online: 2001-01-01
Submitted:
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16. Tolerance of radiotherapy (3D-CRT) and androgen ablation for patients with prostate cancer

P. Milecki, G. Stryczyńska, T. Stachowski, Z. Kwias, M. Matecka-Nowak
DOI: 10.1016/S1507-1367(01)70386-0
·
Rep Pract Oncol Radiother 2001;6(1):34.

open access

Vol 6, No 1 (2001)
Untitled
Published online: 2001-01-01
Submitted:

Abstract

Purpose

Evaluation acute tolerance of combined treatment (XRT and HT).

Material/methods

Between April 1999 and September 2000, 22 patients with prostate cancer (T1-T3NXMO) were treated with 3D-CRT and HT. Median age of patients was 68 years. EBRT was administered daily fraction of 1.8 Gy,total dose 70.2 Gy. Planning target volume (PTV) was defined as clinical target volume CTV (prostate and seminal vesicles) with 10 mm margins around prostate except posterior margin where 5 mm were used to decrease risk of rectum morbidity. Acute toxicities were evaluated using RTOG scoring scale. Median follow-up was 11 months.

Results

Acute effects in gastrointestinal tract (GI) noted were; rectal discomfort and mild diarrhea. Acute genitourinary (GU) symptoms included urgency, nocturia and dysuria. GI toxicity was observed in 75% of patients (grade 0 and 1), and 25% of patients (grade 2). GU toxicities were as follow: grade 0 and 1 – 80% of patients) and grade 2 – (20% of patients). No grade 3 or 4 GI and GU toxicities were observed.

Conclusions

Preliminary results of treatment with 3D-CRT suggested that such modality is well tolerated. HT did not exacerbate radiation toxicity.

Abstract

Purpose

Evaluation acute tolerance of combined treatment (XRT and HT).

Material/methods

Between April 1999 and September 2000, 22 patients with prostate cancer (T1-T3NXMO) were treated with 3D-CRT and HT. Median age of patients was 68 years. EBRT was administered daily fraction of 1.8 Gy,total dose 70.2 Gy. Planning target volume (PTV) was defined as clinical target volume CTV (prostate and seminal vesicles) with 10 mm margins around prostate except posterior margin where 5 mm were used to decrease risk of rectum morbidity. Acute toxicities were evaluated using RTOG scoring scale. Median follow-up was 11 months.

Results

Acute effects in gastrointestinal tract (GI) noted were; rectal discomfort and mild diarrhea. Acute genitourinary (GU) symptoms included urgency, nocturia and dysuria. GI toxicity was observed in 75% of patients (grade 0 and 1), and 25% of patients (grade 2). GU toxicities were as follow: grade 0 and 1 – 80% of patients) and grade 2 – (20% of patients). No grade 3 or 4 GI and GU toxicities were observed.

Conclusions

Preliminary results of treatment with 3D-CRT suggested that such modality is well tolerated. HT did not exacerbate radiation toxicity.

Get Citation
About this article
Title

16. Tolerance of radiotherapy (3D-CRT) and androgen ablation for patients with prostate cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 6, No 1 (2001)

Pages

34

Published online

2001-01-01

DOI

10.1016/S1507-1367(01)70386-0

Bibliographic record

Rep Pract Oncol Radiother 2001;6(1):34.

Authors

P. Milecki
G. Stryczyńska
T. Stachowski
Z. Kwias
M. Matecka-Nowak

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