open access

Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01
Submitted: 2020-06-03
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Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

Somayeh Gholami, Francesco Longo, Sara Shahzadeh, Hassan Ali Nedaie, Ryan Sharp, Ali S.Meigooni
DOI: 10.1016/j.rpor.2020.09.002
·
Rep Pract Oncol Radiother 2020;25(6):961-968.

open access

Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01
Submitted: 2020-06-03

Abstract

Purpose

To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques.

Materials and Methods

The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam.

Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom.

Results

The results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3%, respectively.

Conclusion

MR-linac RT may result in lower NLT complications when compared to conventional RT.

Abstract

Purpose

To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques.

Materials and Methods

The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam.

Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom.

Results

The results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3%, respectively.

Conclusion

MR-linac RT may result in lower NLT complications when compared to conventional RT.

Get Citation

Keywords

Normal lung tissue complications; MR-linac; Geant4 toolkit; XCAT digital phantom

About this article
Title

Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 6 (2020)

Pages

961-968

Published online

2020-11-01

DOI

10.1016/j.rpor.2020.09.002

Bibliographic record

Rep Pract Oncol Radiother 2020;25(6):961-968.

Keywords

Normal lung tissue complications
MR-linac
Geant4 toolkit
XCAT digital phantom

Authors

Somayeh Gholami
Francesco Longo
Sara Shahzadeh
Hassan Ali Nedaie
Ryan Sharp
Ali S.Meigooni

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