Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01

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Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

Somayeh Gholami12, Francesco Longo3, Sara Shahzadeh4, Hassan Ali Nedaie12, Ryan Sharp5, Ali S.Meigooni6
DOI: 10.1016/j.rpor.2020.09.002
Rep Pract Oncol Radiother 2020;25(6):961-968.

Abstract

Purpose

To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques.

Materials and Methods

The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam.

Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom.

Results

The results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3%, respectively.

Conclusion

MR-linac RT may result in lower NLT complications when compared to conventional RT.

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Reports of Practical Oncology and Radiotherapy