open access

Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01
Submitted: 2020-07-24
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Serum cytokine profile as a potential prognostic tool in colorectal cancer patients – one center study

Paulina Czajka-Francuz, Tomasz Francuz, Sylwia Cisoń-Jurek, Aleksander Czajka, Marcin Fajkis, Bożena Szymczak, Maciej Kozaczka, Krzysztof Piotr Malinowski, Wojciech Zasada, Jerzy Wojnar, Jerzy Chudek
DOI: 10.1016/j.rpor.2020.08.004
·
Rep Pract Oncol Radiother 2020;25(6):867-875.

open access

Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01
Submitted: 2020-07-24

Abstract

Aim

Comparison of 14 cytokines levels between a control group and prospectively enrolled CRC patients to confirm their significance in CRC development. We tested if a model based on 14 cytokines levels could predict prognosis in Caucasian CRC patients treated with 5-FU based chemotherapy.

Background

Novel prognostic tools in colorectal cancer (CRC) are necessary to optimize treatment, reduce toxicity and chemotherapy (CHT) costs.

Materials and Methods

We assessed prognostic significance of 14 cytokines: IL-1 beta, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL12p70, IL-13, IL-17A in 75 prospectively enrolled CRC patients before initiation of palliative or adjuvant CHT and in 22 control subjects. Readings were taken using the Bio-Plex 200 System. Response to treatment was assessed after 6 months from initiation of CHT. The treated group was divided depending on the response into a progressors (death, progression of disease) and non-progressors group (stable disease, partial response, complete response).

Results

We found that increased concentration of IL-8 was a negative prognostic factor in the whole group and palliative subgroup, whereas increased level of IL-10, IL-7, and IL-12p70 was a negative predictor in the adjuvant group CHT.

Conclusions

We proposed a statistical model based on circulating cytokine levels, showing a good prognostic value in prediction of the response to CHT (AUC = 0.956). The model, including combined IL-2, IL-8, IL-10 and IL-13 levels, established in the whole treated group, should be validated in larger trials.

Abstract

Aim

Comparison of 14 cytokines levels between a control group and prospectively enrolled CRC patients to confirm their significance in CRC development. We tested if a model based on 14 cytokines levels could predict prognosis in Caucasian CRC patients treated with 5-FU based chemotherapy.

Background

Novel prognostic tools in colorectal cancer (CRC) are necessary to optimize treatment, reduce toxicity and chemotherapy (CHT) costs.

Materials and Methods

We assessed prognostic significance of 14 cytokines: IL-1 beta, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL12p70, IL-13, IL-17A in 75 prospectively enrolled CRC patients before initiation of palliative or adjuvant CHT and in 22 control subjects. Readings were taken using the Bio-Plex 200 System. Response to treatment was assessed after 6 months from initiation of CHT. The treated group was divided depending on the response into a progressors (death, progression of disease) and non-progressors group (stable disease, partial response, complete response).

Results

We found that increased concentration of IL-8 was a negative prognostic factor in the whole group and palliative subgroup, whereas increased level of IL-10, IL-7, and IL-12p70 was a negative predictor in the adjuvant group CHT.

Conclusions

We proposed a statistical model based on circulating cytokine levels, showing a good prognostic value in prediction of the response to CHT (AUC = 0.956). The model, including combined IL-2, IL-8, IL-10 and IL-13 levels, established in the whole treated group, should be validated in larger trials.

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Keywords

biomarker; cytokine; prognosis; tumor microenvironment; colon cancer

About this article
Title

Serum cytokine profile as a potential prognostic tool in colorectal cancer patients – one center study

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 6 (2020)

Pages

867-875

Published online

2020-11-01

DOI

10.1016/j.rpor.2020.08.004

Bibliographic record

Rep Pract Oncol Radiother 2020;25(6):867-875.

Keywords

biomarker
cytokine
prognosis
tumor microenvironment
colon cancer

Authors

Paulina Czajka-Francuz
Tomasz Francuz
Sylwia Cisoń-Jurek
Aleksander Czajka
Marcin Fajkis
Bożena Szymczak
Maciej Kozaczka
Krzysztof Piotr Malinowski
Wojciech Zasada
Jerzy Wojnar
Jerzy Chudek

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