open access

Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01
Submitted: 2019-04-23
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Surgery versus radiotherapy: Long term outcomes of T1 glottic cancer

Nelson Ferreira, Eduardo Netto, Leonor Fonseca, João Fonseca, Susana Esteves, Miguel Labareda, António Mota, Rute Pocinho, Miguel Magalhães, Filomena Santos
DOI: 10.1016/j.rpor.2020.08.007
·
Rep Pract Oncol Radiother 2020;25(6):860-866.

open access

Vol 25, No 6 (2020)
Original research articles
Published online: 2020-11-01
Submitted: 2019-04-23

Abstract

Aim

The aim of this study was to compare the outcomes, patterns of failure and laryngeal preservation rates in patients with T1N0 glottic cancer treated with surgery or radiotherapy.

Materials/methods

Retrospective study of T1N0 glottic cancer patients treated in our institution between January 2007 and December 2017. Histologically proven squamous cell carcinoma patients, treated with upfront cordectomy/partial laryngectomy (S group) or radiotherapy (RT group) were included. Elective treatment of the neck was not permitted. Local failure (LF), disease-free survival (DFS), ultimate disease-free survival (UDFS), laryngectomy-free survival (LFS), disease-specific mortality (DSM) and overall survival (OS) were evaluated.

Results

Two hundred and one patients were eligible (172 S group, 29 RT group), with a median follow-up of 38.8 months. Overall, 33 (16%) patients had a recurrence, 30 (17%) in the S group and 3 (10%) in the RT group. Local failure was the predominant site of failure (28 S, 2 RT). Overall, of all those that were salvaged, 17 (8%) underwent total laryngectomy (15 S, 2 RT). There was no significant difference in the 5-year cumulative incidence of LF (20.8% S, 8.1% RT, p=0.138), 5-y LFS (85.0% vs. 91.7%, p=0.809), 5-y DFS (67.5% vs. 82.1%, p=0.343), 5-y UDFS (82.5% vs. 90.3%, p=0.647) and 5-y OS (84.5% vs. 90.3%, p=0.892). Multivariate analysis showed no correlation between initial treatment and the analyzed outcomes.

Conclusion

Primary surgery or radiotherapy were similar first line options, since they do not differ in all outcomes. Patients’ and physician's preferences must be considered when choosing first treatment.

Abstract

Aim

The aim of this study was to compare the outcomes, patterns of failure and laryngeal preservation rates in patients with T1N0 glottic cancer treated with surgery or radiotherapy.

Materials/methods

Retrospective study of T1N0 glottic cancer patients treated in our institution between January 2007 and December 2017. Histologically proven squamous cell carcinoma patients, treated with upfront cordectomy/partial laryngectomy (S group) or radiotherapy (RT group) were included. Elective treatment of the neck was not permitted. Local failure (LF), disease-free survival (DFS), ultimate disease-free survival (UDFS), laryngectomy-free survival (LFS), disease-specific mortality (DSM) and overall survival (OS) were evaluated.

Results

Two hundred and one patients were eligible (172 S group, 29 RT group), with a median follow-up of 38.8 months. Overall, 33 (16%) patients had a recurrence, 30 (17%) in the S group and 3 (10%) in the RT group. Local failure was the predominant site of failure (28 S, 2 RT). Overall, of all those that were salvaged, 17 (8%) underwent total laryngectomy (15 S, 2 RT). There was no significant difference in the 5-year cumulative incidence of LF (20.8% S, 8.1% RT, p=0.138), 5-y LFS (85.0% vs. 91.7%, p=0.809), 5-y DFS (67.5% vs. 82.1%, p=0.343), 5-y UDFS (82.5% vs. 90.3%, p=0.647) and 5-y OS (84.5% vs. 90.3%, p=0.892). Multivariate analysis showed no correlation between initial treatment and the analyzed outcomes.

Conclusion

Primary surgery or radiotherapy were similar first line options, since they do not differ in all outcomes. Patients’ and physician's preferences must be considered when choosing first treatment.

Get Citation

Keywords

Glottic cancer; T1; Radiotherapy; Surgery; Larynx preservation; Outcome

About this article
Title

Surgery versus radiotherapy: Long term outcomes of T1 glottic cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 6 (2020)

Pages

860-866

Published online

2020-11-01

DOI

10.1016/j.rpor.2020.08.007

Bibliographic record

Rep Pract Oncol Radiother 2020;25(6):860-866.

Keywords

Glottic cancer
T1
Radiotherapy
Surgery
Larynx preservation
Outcome

Authors

Nelson Ferreira
Eduardo Netto
Leonor Fonseca
João Fonseca
Susana Esteves
Miguel Labareda
António Mota
Rute Pocinho
Miguel Magalhães
Filomena Santos

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