open access

Vol 25, No 5 (2020)
Reviews
Published online: 2020-09-01
Submitted: 2019-12-18
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Good or not good: Role of miR-18a in cancer biology

Tomasz Kolenda, Kacper Guglas, Magda Kopczyńska, Joanna Sobocińska, Anna Teresiak, Renata Bliźniak, Katarzyna Lamperska
DOI: 10.1016/j.rpor.2020.07.006
·
Rep Pract Oncol Radiother 2020;25(5):808-819.

open access

Vol 25, No 5 (2020)
Reviews
Published online: 2020-09-01
Submitted: 2019-12-18

Abstract

miR-18a is a member of primary transcript called miR-17-92a (C13orf25 or MIR17HG) which also contains five other miRNAs: miR-17, miR-19a, miR-20a, miR-19b and miR-92a. This cluster as a whole shows specific characteristics, where miR-18a seems to be unique. In contrast to the other members, the expression of miR-18a is additionally controlled and probably functions as its own internal controller of the cluster. miR-18a regulates many genes involved in proliferation, cell cycle, apoptosis, response to different kinds of stress, autophagy and differentiation. The disturbances of miR-18a expression are observed in cancer as well as in different diseases or pathological states. The miR-17-92a cluster is commonly described as oncogenic and it is known as ‘oncomiR-1’, but this statement is a simplification because miR-18a can act both as an oncogene and a suppressor.

In this review we summarize the current knowledge about miR-18a focusing on its regulation, role in cancer biology and utility as a potential biomarker.

Abstract

miR-18a is a member of primary transcript called miR-17-92a (C13orf25 or MIR17HG) which also contains five other miRNAs: miR-17, miR-19a, miR-20a, miR-19b and miR-92a. This cluster as a whole shows specific characteristics, where miR-18a seems to be unique. In contrast to the other members, the expression of miR-18a is additionally controlled and probably functions as its own internal controller of the cluster. miR-18a regulates many genes involved in proliferation, cell cycle, apoptosis, response to different kinds of stress, autophagy and differentiation. The disturbances of miR-18a expression are observed in cancer as well as in different diseases or pathological states. The miR-17-92a cluster is commonly described as oncogenic and it is known as ‘oncomiR-1’, but this statement is a simplification because miR-18a can act both as an oncogene and a suppressor.

In this review we summarize the current knowledge about miR-18a focusing on its regulation, role in cancer biology and utility as a potential biomarker.

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Keywords

5-FU; ACVR2A; AKT; AR; ATG7; ATM; BAX; BCL2; BCL2L10; BDNF; Bp; C-myc (MYCBP); CASC2; CD133 (PROM1); CDC42; CDKN1; ceRNA; cncRNA; DDR; E2F family (E2F1, E2F2, E2F3); EBV; EMT; ER; ERBB (EGFR); FENDRR; FER1L4; GAS5; HIF-1α (HIF1A); HNRNPA1; HRR; IFN-γ (IFNG); IGF1; IL6; IPMK; KRAS; LMP1; lncRNA; MAPK; MCM7; MET; MTOR; N-myc (MYCN); NF-κB; NOTCH2; PERK (EIF2AK3); PI3K (PIK3CA); PIAS3; RISC; SMAD2; SMG1; SNHG1; SOCS5; STAT3; STK4; TCGA; TGF-β (TGFB1); TGFBR2; TNM; TP53; TP53TG1; TRIAP1; TSC1; UCA1; UTR; WDFY3-AS2; WEE1; WNT family; ZEB1/ZEB2; COAD; UCEC; BLCA; HNSC; LUAD; STAD; KIRC; PRAD; BRCA; ESCA; LUSC; LIHC; KIRP; PAAD; THCA; miR-18a; miR-17-92a; miRNA; Cancer; TCGA; Oncogene; Suppressor; Biomarker; Circulating miRNA; Liquid biopsy

About this article
Title

Good or not good: Role of miR-18a in cancer biology

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 5 (2020)

Pages

808-819

Published online

2020-09-01

DOI

10.1016/j.rpor.2020.07.006

Bibliographic record

Rep Pract Oncol Radiother 2020;25(5):808-819.

Keywords

5-FU
ACVR2A
AKT
AR
ATG7
ATM
BAX
BCL2
BCL2L10
BDNF
Bp
C-myc (MYCBP)
CASC2
CD133 (PROM1)
CDC42
CDKN1
ceRNA
cncRNA
DDR
E2F family (E2F1
E2F2
E2F3)
EBV
EMT
ER
ERBB (EGFR)
FENDRR
FER1L4
GAS5
HIF-1α (HIF1A)
HNRNPA1
HRR
IFN-γ (IFNG)
IGF1
IL6
IPMK
KRAS
LMP1
lncRNA
MAPK
MCM7
MET
MTOR
N-myc (MYCN)
NF-κB
NOTCH2
PERK (EIF2AK3)
PI3K (PIK3CA)
PIAS3
RISC
SMAD2
SMG1
SNHG1
SOCS5
STAT3
STK4
TCGA
TGF-β (TGFB1)
TGFBR2
TNM
TP53
TP53TG1
TRIAP1
TSC1
UCA1
UTR
WDFY3-AS2
WEE1
WNT family
ZEB1/ZEB2
COAD
UCEC
BLCA
HNSC
LUAD
STAD
KIRC
PRAD
BRCA
ESCA
LUSC
LIHC
KIRP
PAAD
THCA
miR-18a
miR-17-92a
miRNA
Cancer
TCGA
Oncogene
Suppressor
Biomarker
Circulating miRNA
Liquid biopsy

Authors

Tomasz Kolenda
Kacper Guglas
Magda Kopczyńska
Joanna Sobocińska
Anna Teresiak
Renata Bliźniak
Katarzyna Lamperska

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