open access

Vol 25, No 4 (2020)
Original research articles
Published online: 2020-07-01
Submitted: 2020-01-16
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Risk factors of recurrence after postoperative electron beam radiation therapy for keloid: Comparison of long-term local control rate

Hitoshi Maemoto, Shiro Iraha, Ken Arashiro, Kousei Ishigami, Fumikiyo Ganaha, Sadayuki Murayama
DOI: 10.1016/j.rpor.2020.05.001
·
Rep Pract Oncol Radiother 2020;25(4):606-611.

open access

Vol 25, No 4 (2020)
Original research articles
Published online: 2020-07-01
Submitted: 2020-01-16

Abstract

Aim

To investigate the new risk factors for keloid recurrence after postoperative electron beam radiotherapy (RT) and evaluate the effectiveness of tranilast in combination with electron beam RT by comparing the local control rate.

Background

Identifying patients at high risk of recurrence after postoperative RT for keloids remains a challenge. Besides, no study examined the effectiveness of tranilast in combination with RT after surgery for the prevention of keloids recurrence.

Materials and Methods

This study included 75 lesions in 59 consecutive patients who had undergone postoperative RT at our institute. The follow-up period and prescription of tranilast were examined beside several potential risk factors, such as multiple lesions, size, and shape.

Results

The median follow-up was 72 months (range, 6–147 months). Twenty-one lesions in 17 patients recurred in a median of 12 months after treatment (range, 1–60 months). Local control rates of all 75 lesions were estimated as 93%, 78%, 70%, and 68% at 1, 2, 5, and 10 years. Multiple lesions constituted a significant risk of recurrence (P = 0.03). A larger long axis was significantly related to the recurrence (P < 0.01). Irregular shape was associated with a significantly worse local control rate (P = 0.02). There was no significant difference in the local control rate between patients receiving tranilast and those who did not (P = 0.52).

Conclusions

Multiple lesions and irregular shape were risk factors of keloid recurrence after postoperative electron beam RT. The effectiveness of tranilast was not demonstrated in the study.

Abstract

Aim

To investigate the new risk factors for keloid recurrence after postoperative electron beam radiotherapy (RT) and evaluate the effectiveness of tranilast in combination with electron beam RT by comparing the local control rate.

Background

Identifying patients at high risk of recurrence after postoperative RT for keloids remains a challenge. Besides, no study examined the effectiveness of tranilast in combination with RT after surgery for the prevention of keloids recurrence.

Materials and Methods

This study included 75 lesions in 59 consecutive patients who had undergone postoperative RT at our institute. The follow-up period and prescription of tranilast were examined beside several potential risk factors, such as multiple lesions, size, and shape.

Results

The median follow-up was 72 months (range, 6–147 months). Twenty-one lesions in 17 patients recurred in a median of 12 months after treatment (range, 1–60 months). Local control rates of all 75 lesions were estimated as 93%, 78%, 70%, and 68% at 1, 2, 5, and 10 years. Multiple lesions constituted a significant risk of recurrence (P = 0.03). A larger long axis was significantly related to the recurrence (P < 0.01). Irregular shape was associated with a significantly worse local control rate (P = 0.02). There was no significant difference in the local control rate between patients receiving tranilast and those who did not (P = 0.52).

Conclusions

Multiple lesions and irregular shape were risk factors of keloid recurrence after postoperative electron beam RT. The effectiveness of tranilast was not demonstrated in the study.

Get Citation

Keywords

keloid; hypertrophic scar; radiation; tranilast

About this article
Title

Risk factors of recurrence after postoperative electron beam radiation therapy for keloid: Comparison of long-term local control rate

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 4 (2020)

Pages

606-611

Published online

2020-07-01

DOI

10.1016/j.rpor.2020.05.001

Bibliographic record

Rep Pract Oncol Radiother 2020;25(4):606-611.

Keywords

keloid
hypertrophic scar
radiation
tranilast

Authors

Hitoshi Maemoto
Shiro Iraha
Ken Arashiro
Kousei Ishigami
Fumikiyo Ganaha
Sadayuki Murayama

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