open access

Vol 25, No 4 (2020)
Original research articles
Published online: 2020-07-01
Submitted: 2019-10-05
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Total skin electron beam therapy for primary cutaneous T-cell lymphomas: clinical characteristics and outcomes in a Mexican reference center

Ch Flores-Balcázar, DM Urías-Arce, Y Charli-Joseph, MA De León-Alfaro, SI Pérez-Álvarez, R Ramos-Prudencio
DOI: 10.1016/j.rpor.2020.03.020
·
Rep Pract Oncol Radiother 2020;25(4):562-567.

open access

Vol 25, No 4 (2020)
Original research articles
Published online: 2020-07-01
Submitted: 2019-10-05

Abstract

Aim

The aim of this study was to assess treatment modalities, treatment response, toxicity profile, disease progression and outcomes in 14 patients with a confirmed diagnosis of primary cutaneous T-cell lymphoma (PCTCL) treated with total skin electron beam therapy (TSEBT).

Background

Primary cutaneous lymphomas (PCLs) are extranodal non-Hodgkin lymphomas originating in the skin without evidence of extracutaneous disease at diagnosis. Despite advances in systemic and local therapy options, the management of advanced stages remains mostly palliative.

Materials and Methods

This is a retrospective study of patients with PCTCL, diagnosed and treated in a reference center in Mexico City, analyzing treatment modalities, response to treatment, long-term outcome, and mortality.

Results

Eight males (57%) and 6 (43%) females were identified. Most patients were stage IVA (n = 5, 36%) followed by stage IB and IIB (28.5% and 21.4%, respectively). Eleven patients received the low-dose RT scheme (12 Gy), 1 patient, the intermediate-dose RT scheme (24 Gy), and 2 patients, the conventional-dose RT scheme (36 Gy). Mean follow-up time was 4.6 years. At first follow-up examination, 6–8 weeks after radiotherapy, the overall response rate (ORR) for the cohort was 85%. The median PFS for the whole cohort was 6 months.

Conclusion

This study reinforces the role of TSEBT when compared with other treatment modalities and novel agents. Low-dose TSEBT is now widely used because of the opportunity for retreatment.

Abstract

Aim

The aim of this study was to assess treatment modalities, treatment response, toxicity profile, disease progression and outcomes in 14 patients with a confirmed diagnosis of primary cutaneous T-cell lymphoma (PCTCL) treated with total skin electron beam therapy (TSEBT).

Background

Primary cutaneous lymphomas (PCLs) are extranodal non-Hodgkin lymphomas originating in the skin without evidence of extracutaneous disease at diagnosis. Despite advances in systemic and local therapy options, the management of advanced stages remains mostly palliative.

Materials and Methods

This is a retrospective study of patients with PCTCL, diagnosed and treated in a reference center in Mexico City, analyzing treatment modalities, response to treatment, long-term outcome, and mortality.

Results

Eight males (57%) and 6 (43%) females were identified. Most patients were stage IVA (n = 5, 36%) followed by stage IB and IIB (28.5% and 21.4%, respectively). Eleven patients received the low-dose RT scheme (12 Gy), 1 patient, the intermediate-dose RT scheme (24 Gy), and 2 patients, the conventional-dose RT scheme (36 Gy). Mean follow-up time was 4.6 years. At first follow-up examination, 6–8 weeks after radiotherapy, the overall response rate (ORR) for the cohort was 85%. The median PFS for the whole cohort was 6 months.

Conclusion

This study reinforces the role of TSEBT when compared with other treatment modalities and novel agents. Low-dose TSEBT is now widely used because of the opportunity for retreatment.

Get Citation

Keywords

Cutaneous lymphoma; Mycosis fungoides; Sézary syndrome; Total skin electron beam therapy.; CI; CR; EORTC; LCT; LPD; MF; NHL; ORR; OS; PCL; PCTCL; PFS; RT; SD; SS; TSEBT; UV

About this article
Title

Total skin electron beam therapy for primary cutaneous T-cell lymphomas: clinical characteristics and outcomes in a Mexican reference center

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 4 (2020)

Pages

562-567

Published online

2020-07-01

DOI

10.1016/j.rpor.2020.03.020

Bibliographic record

Rep Pract Oncol Radiother 2020;25(4):562-567.

Keywords

Cutaneous lymphoma
Mycosis fungoides
Sézary syndrome
Total skin electron beam therapy.
CI
CR
EORTC
LCT
LPD
MF
NHL
ORR
OS
PCL
PCTCL
PFS
RT
SD
SS
TSEBT
UV

Authors

Ch Flores-Balcázar
DM Urías-Arce
Y Charli-Joseph
MA De León-Alfaro
SI Pérez-Álvarez
R Ramos-Prudencio

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