open access

Vol 25, No 3 (2020)
Published online: 2020-05-01
Submitted: 2019-11-26
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Neck emphysema in a HNSCC cancer patient undergoing concurrent radiotherapy and cetuximab

Valerio Nardone, Maria Grazia Calvanese, Ida D’Onofrio, Mario Di Stasio, Claudio Vitale, Antonia Silvestri, Bruno Daniele, Pierpaolo Correale, Paolo Fierro, Giuseppe Tortoriello, Alfonso Reginelli, Salvatore Cappabianca, Cesare Guida
DOI: 10.1016/j.rpor.2020.03.025
·
Rep Pract Oncol Radiother 2020;25(3):396-398.

open access

Vol 25, No 3 (2020)
Published online: 2020-05-01
Submitted: 2019-11-26

Abstract

Background

Lung toxicity in patients undergoing cetuximab and radiotherapy (Cetux-RT) for head and neck squamous cell carcinoma (HNSCC) has been reported in literature and represents a serious side effect of concurrent therapies.

Methods

We report a case of a HNSCC patient that developed neck emphysema during the course of Cetux-RT. The patient was an old male (80 years old) in a good performance status, with an oropharyngeal cancer (T4aN3a).

Results

During RT, cone-beam computed tomography (CBCT) showed bilateral neck emphysema that was confirmed at restaging CT. We decided to stop the treatment and to treat the neck emphysema with conservative strategies. After one week CT was repeated and the neck emphysema had improved, so we decided to complete the RT treatment.

Conclusions

Patients undergoing Cetux-RT must be properly selected, whereas IGRT imaging must be viewed carefully in order to permit an early diagnosis and careful management of the patients.

Abstract

Background

Lung toxicity in patients undergoing cetuximab and radiotherapy (Cetux-RT) for head and neck squamous cell carcinoma (HNSCC) has been reported in literature and represents a serious side effect of concurrent therapies.

Methods

We report a case of a HNSCC patient that developed neck emphysema during the course of Cetux-RT. The patient was an old male (80 years old) in a good performance status, with an oropharyngeal cancer (T4aN3a).

Results

During RT, cone-beam computed tomography (CBCT) showed bilateral neck emphysema that was confirmed at restaging CT. We decided to stop the treatment and to treat the neck emphysema with conservative strategies. After one week CT was repeated and the neck emphysema had improved, so we decided to complete the RT treatment.

Conclusions

Patients undergoing Cetux-RT must be properly selected, whereas IGRT imaging must be viewed carefully in order to permit an early diagnosis and careful management of the patients.

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Keywords

Neck emphysema; HNSCC; Cetuximab; Radiation therapy

About this article
Title

Neck emphysema in a HNSCC cancer patient undergoing concurrent radiotherapy and cetuximab

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 3 (2020)

Pages

396-398

Published online

2020-05-01

DOI

10.1016/j.rpor.2020.03.025

Bibliographic record

Rep Pract Oncol Radiother 2020;25(3):396-398.

Keywords

Neck emphysema
HNSCC
Cetuximab
Radiation therapy

Authors

Valerio Nardone
Maria Grazia Calvanese
Ida D’Onofrio
Mario Di Stasio
Claudio Vitale
Antonia Silvestri
Bruno Daniele
Pierpaolo Correale
Paolo Fierro
Giuseppe Tortoriello
Alfonso Reginelli
Salvatore Cappabianca
Cesare Guida

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