open access

Vol 25, No 3 (2020)
Reviews
Published online: 2020-05-01
Submitted: 2019-09-25
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Detection of radiation induced cardiotoxicity: Role of echocardiography and biomarkers

Radek Pudil
DOI: 10.1016/j.rpor.2020.02.012
·
Rep Pract Oncol Radiother 2020;25(3):327-330.

open access

Vol 25, No 3 (2020)
Reviews
Published online: 2020-05-01
Submitted: 2019-09-25

Abstract

We review the role of echocardiography and biomarkers in detection of radiation-induced cardiac toxicity (RICT). RICT is related to micro- and macrovascular damage which induce inflammation, endothelial dysfunction, accelerated atherosclerosis, myocyte degeneration and fibrosis. The process is cumulative dose to the heart and target volume dependent. Furthermore, the damage of the heart is frequently potentiated by the adjunctive chemotherapy. The clinical manifestations of RICT may acutely develop but most often become clinically apparent several years after irradiation. RICT clinical manifestation covers a wide spectrum of pathologies including pericarditis, coronary artery disease (CAD), myocardial infarction, valvular heart disease, rhythm abnormalities, and non-ischemic myocardial and conduction system damages. Echocardiography and cardiac markers are important diagnostic tools for the detection of RICT.

Abstract

We review the role of echocardiography and biomarkers in detection of radiation-induced cardiac toxicity (RICT). RICT is related to micro- and macrovascular damage which induce inflammation, endothelial dysfunction, accelerated atherosclerosis, myocyte degeneration and fibrosis. The process is cumulative dose to the heart and target volume dependent. Furthermore, the damage of the heart is frequently potentiated by the adjunctive chemotherapy. The clinical manifestations of RICT may acutely develop but most often become clinically apparent several years after irradiation. RICT clinical manifestation covers a wide spectrum of pathologies including pericarditis, coronary artery disease (CAD), myocardial infarction, valvular heart disease, rhythm abnormalities, and non-ischemic myocardial and conduction system damages. Echocardiography and cardiac markers are important diagnostic tools for the detection of RICT.

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Keywords

Radiation induced cardiotoxicity; Echocardiography; Cardiac troponin; Natriuretic peptide

About this article
Title

Detection of radiation induced cardiotoxicity: Role of echocardiography and biomarkers

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 3 (2020)

Pages

327-330

Published online

2020-05-01

DOI

10.1016/j.rpor.2020.02.012

Bibliographic record

Rep Pract Oncol Radiother 2020;25(3):327-330.

Keywords

Radiation induced cardiotoxicity
Echocardiography
Cardiac troponin
Natriuretic peptide

Authors

Radek Pudil

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