open access

Vol 25, No 3 (2020)
Original research articles
Published online: 2020-05-01
Submitted: 2019-11-04
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The effect of radiation therapy on post-prostatectomy urinary function

David K. Jenkins, Gregory P. Swanson, Sameer G. Jhavar, Kristofer R. Wagner, Chul S. Ha, Wencong Chen
DOI: 10.1016/j.rpor.2020.03.019
·
Rep Pract Oncol Radiother 2020;25(3):442-446.

open access

Vol 25, No 3 (2020)
Original research articles
Published online: 2020-05-01
Submitted: 2019-11-04

Abstract

Aim

We sought to evaluate the effect of radiation therapy on post-prostatectomy urinary quality of life in prostate cancer patients.

Background

In some men with non-metastatic prostate cancer, radiation therapy is indicated following prostatectomy. The radiation toxicity and quality of life considerations are unique in the post-prostatectomy setting.

Materials and methods

A total of 106 patients receiving post-prostatectomy radiation therapy completed the Expanded Prostate Cancer Index Composite questionnaire before radiation and at 2-year follow-up. The primary outcomes of this study were the urinary domain summary score and subscale scores. Planned analysis was performed based on time interval from prostatectomy to radiation therapy.

Results

Among the 106 patients analyzed, the mean urinary domain summary score worsened at 2-year follow-up after radiation therapy, lowering from 77.23–72.51 (p = 0.0085). Similar worsening was observed in the subscales of function (p = 0.003), bother (p = 0.0397), and incontinence (p = 0.0003). Urinary incontinence showed the greatest observable change among subscales. While the summary score worsened (p = 0.0031) among patients receiving radiation therapy more than 1 year after prostatectomy, it did not show statistically significant change in those treated 1 year or less after prostatectomy.

Conclusion

Our results demonstrate that post-prostatectomy radiation therapy is associated with modest declines in reportable urinary quality of life. Patients receiving radiation therapy more than 1 year after prostatectomy showed greater worsening of urinary quality of life, which indicates that there may be no functional advantage to delaying radiation therapy beyond the initial postoperative period.

Abstract

Aim

We sought to evaluate the effect of radiation therapy on post-prostatectomy urinary quality of life in prostate cancer patients.

Background

In some men with non-metastatic prostate cancer, radiation therapy is indicated following prostatectomy. The radiation toxicity and quality of life considerations are unique in the post-prostatectomy setting.

Materials and methods

A total of 106 patients receiving post-prostatectomy radiation therapy completed the Expanded Prostate Cancer Index Composite questionnaire before radiation and at 2-year follow-up. The primary outcomes of this study were the urinary domain summary score and subscale scores. Planned analysis was performed based on time interval from prostatectomy to radiation therapy.

Results

Among the 106 patients analyzed, the mean urinary domain summary score worsened at 2-year follow-up after radiation therapy, lowering from 77.23–72.51 (p = 0.0085). Similar worsening was observed in the subscales of function (p = 0.003), bother (p = 0.0397), and incontinence (p = 0.0003). Urinary incontinence showed the greatest observable change among subscales. While the summary score worsened (p = 0.0031) among patients receiving radiation therapy more than 1 year after prostatectomy, it did not show statistically significant change in those treated 1 year or less after prostatectomy.

Conclusion

Our results demonstrate that post-prostatectomy radiation therapy is associated with modest declines in reportable urinary quality of life. Patients receiving radiation therapy more than 1 year after prostatectomy showed greater worsening of urinary quality of life, which indicates that there may be no functional advantage to delaying radiation therapy beyond the initial postoperative period.

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Keywords

Prostate; Radiotherapy; Incontinence; Postoperative; Toxicity.; EBRT; EPIC; IPSS; MID; QOL; RT

About this article
Title

The effect of radiation therapy on post-prostatectomy urinary function

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 3 (2020)

Pages

442-446

Published online

2020-05-01

DOI

10.1016/j.rpor.2020.03.019

Bibliographic record

Rep Pract Oncol Radiother 2020;25(3):442-446.

Keywords

Prostate
Radiotherapy
Incontinence
Postoperative
Toxicity.
EBRT
EPIC
IPSS
MID
QOL
RT

Authors

David K. Jenkins
Gregory P. Swanson
Sameer G. Jhavar
Kristofer R. Wagner
Chul S. Ha
Wencong Chen

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