open access

Vol 25, No 3 (2020)
Original research articles
Published online: 2020-05-01
Submitted: 2019-09-13
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Interplay between inflammation and cancer

Igor Piotrowski, Katarzyna Kulcenty, Wiktoria Suchorska
DOI: 10.1016/j.rpor.2020.04.004
·
Rep Pract Oncol Radiother 2020;25(3):422-427.

open access

Vol 25, No 3 (2020)
Original research articles
Published online: 2020-05-01
Submitted: 2019-09-13

Abstract

Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that cancer development is strongly influenced by both chronic and acute inflammation process. Progress in research on inflammation revealed a connection between inflammatory processes and neoplastic transformation, the progression of tumour, and the development of metastases and recurrences. Moreover, the tumour invasive procedures (both surgery and biopsy) affect the remaining tumour cells by increasing their survival, proliferation and migration. One of the concepts explaining this phenomena is an induction of a wound healing response. While in normal tissue it is necessary for tissue repair, in tumour tissue, induction of adaptive and innate immune response related to wound healing, stimulates tumour cell survival, angiogenesis and extravasation of circulating tumour cells. It has become evident that certain types of immune response and immune cells can promote tumour progression more than others. In this review, we focus on current knowledge on carcinogenesis and promotion of cancer growth induced by inflammatory processes.

Abstract

Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that cancer development is strongly influenced by both chronic and acute inflammation process. Progress in research on inflammation revealed a connection between inflammatory processes and neoplastic transformation, the progression of tumour, and the development of metastases and recurrences. Moreover, the tumour invasive procedures (both surgery and biopsy) affect the remaining tumour cells by increasing their survival, proliferation and migration. One of the concepts explaining this phenomena is an induction of a wound healing response. While in normal tissue it is necessary for tissue repair, in tumour tissue, induction of adaptive and innate immune response related to wound healing, stimulates tumour cell survival, angiogenesis and extravasation of circulating tumour cells. It has become evident that certain types of immune response and immune cells can promote tumour progression more than others. In this review, we focus on current knowledge on carcinogenesis and promotion of cancer growth induced by inflammatory processes.

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Keywords

Inflammation; Cancer; Tumor reccurence; ANGPTL4; bFGF; CDH1; COX; EMT; EP; GI; IL-6; iNOS; MPO; NADPH; NFκB; NK; NO; NSAIDs; PGE2; PTHrP; RNS; ROS; STAT3; TGFBRII; TGF-β; TNFR1; TNFR2; TNF-α; VEGF

About this article
Title

Interplay between inflammation and cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 3 (2020)

Pages

422-427

Published online

2020-05-01

DOI

10.1016/j.rpor.2020.04.004

Bibliographic record

Rep Pract Oncol Radiother 2020;25(3):422-427.

Keywords

Inflammation
Cancer
Tumor reccurence
ANGPTL4
bFGF
CDH1
COX
EMT
EP
GI
IL-6
iNOS
MPO
NADPH
NFκB
NK
NO
NSAIDs
PGE2
PTHrP
RNS
ROS
STAT3
TGFBRII
TGF-β
TNFR1
TNFR2
TNF-α
VEGF

Authors

Igor Piotrowski
Katarzyna Kulcenty
Wiktoria Suchorska

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