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Interplay between inflammation and cancer
Affiliations- Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Garbary 15 Street, 61-866 Poznań, Poland
- Department of Electroradiology, University of Medical Sciences, Garbary 15 Street, 61-866 Poznań, Poland
open access
Abstract
Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that cancer development is strongly influenced by both chronic and acute inflammation process. Progress in research on inflammation revealed a connection between inflammatory processes and neoplastic transformation, the progression of tumour, and the development of metastases and recurrences. Moreover, the tumour invasive procedures (both surgery and biopsy) affect the remaining tumour cells by increasing their survival, proliferation and migration. One of the concepts explaining this phenomena is an induction of a wound healing response. While in normal tissue it is necessary for tissue repair, in tumour tissue, induction of adaptive and innate immune response related to wound healing, stimulates tumour cell survival, angiogenesis and extravasation of circulating tumour cells. It has become evident that certain types of immune response and immune cells can promote tumour progression more than others. In this review, we focus on current knowledge on carcinogenesis and promotion of cancer growth induced by inflammatory processes.
Abstract
Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that cancer development is strongly influenced by both chronic and acute inflammation process. Progress in research on inflammation revealed a connection between inflammatory processes and neoplastic transformation, the progression of tumour, and the development of metastases and recurrences. Moreover, the tumour invasive procedures (both surgery and biopsy) affect the remaining tumour cells by increasing their survival, proliferation and migration. One of the concepts explaining this phenomena is an induction of a wound healing response. While in normal tissue it is necessary for tissue repair, in tumour tissue, induction of adaptive and innate immune response related to wound healing, stimulates tumour cell survival, angiogenesis and extravasation of circulating tumour cells. It has become evident that certain types of immune response and immune cells can promote tumour progression more than others. In this review, we focus on current knowledge on carcinogenesis and promotion of cancer growth induced by inflammatory processes.
Keywords
Inflammation; Cancer; Tumor reccurence; ANGPTL4; bFGF; CDH1; COX; EMT; EP; GI; IL-6; iNOS; MPO; NADPH; NFκB; NK; NO; NSAIDs; PGE2; PTHrP; RNS; ROS; STAT3; TGFBRII; TGF-β; TNFR1; TNFR2; TNF-α; VEGF
About this articleTitle
Interplay between inflammation and cancer
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
422-427
Published online
2020-05-01
Page views
699
Article views/downloads
489
DOI
10.1016/j.rpor.2020.04.004
Bibliographic record
Rep Pract Oncol Radiother 2020;25(3):422-427.
Keywords
Inflammation
Cancer
Tumor reccurence
ANGPTL4
bFGF
CDH1
COX
EMT
EP
GI
IL-6
iNOS
MPO
NADPH
NFκB
NK
NO
NSAIDs
PGE2
PTHrP
RNS
ROS
STAT3
TGFBRII
TGF-β
TNFR1
TNFR2
TNF-α
VEGF
Authors
Igor Piotrowski
Katarzyna Kulcenty
Wiktoria Suchorska