Vol 25, No 3 (2020)
Original research articles
Published online: 2020-05-01

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Interplay between inflammation and cancer

Igor Piotrowski12, Katarzyna Kulcenty12, Wiktoria Suchorska1
DOI: 10.1016/j.rpor.2020.04.004
Rep Pract Oncol Radiother 2020;25(3):422-427.

Abstract

Tumor-promoting inflammation is one of the hallmarks of cancer. It has been shown that cancer development is strongly influenced by both chronic and acute inflammation process. Progress in research on inflammation revealed a connection between inflammatory processes and neoplastic transformation, the progression of tumour, and the development of metastases and recurrences. Moreover, the tumour invasive procedures (both surgery and biopsy) affect the remaining tumour cells by increasing their survival, proliferation and migration. One of the concepts explaining this phenomena is an induction of a wound healing response. While in normal tissue it is necessary for tissue repair, in tumour tissue, induction of adaptive and innate immune response related to wound healing, stimulates tumour cell survival, angiogenesis and extravasation of circulating tumour cells. It has become evident that certain types of immune response and immune cells can promote tumour progression more than others. In this review, we focus on current knowledge on carcinogenesis and promotion of cancer growth induced by inflammatory processes.

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Reports of Practical Oncology and Radiotherapy