Vol 25, No 3 (2020)
Original research articles
Published online: 2020-05-01

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Impact of bone events on survival in solitary bone plasmacytoma

Geovanne Pedro Mauro1, Pedro Pereira Neffá2, Rosangela Correa Villar34, Gracia Aparecida Martinez2, Heloísa de Carvalho35
DOI: 10.1016/j.rpor.2020.04.002
Rep Pract Oncol Radiother 2020;25(3):389-395.



Although much studied in multiple myeloma, bone events (BE) can also cause important morbidity in bone plasmacytoma patients. To our knowledge, the effect of BE on overall survival (OS) and progression to multiple myeloma free-survival (MPFS) also has never been studied.

Patients and Methods

Fifty-nine patients treated from 2008 to 2017 were retrospectively assessed. All patients had histological proof of disease and were treated with radical radiotherapy (RT). Available clinical information for at least 6 months follow-up or until death had to be available. BE were described as one of the following events in the index bone: fractures, osteomyelitis, chronic pain, surgery or loss of limb function after RT.


Mean age at diagnosis was 57.3 years (18–80); most male (67.8%). Mean OS, bone event free-survival (BEFS), local progression-free survival (LPFS) and MPFS were 41, 36, 37 and 19 months, respectively. There were 15 deaths. BEFS (p = 0.008) and age>55y (p = 0.044) were associated with MPFS. Only BEFS correlated with OS (p = 0.029). BE was independently associated with both MPFS and OS in multivariate analysis.


BE and survival end-points were correlated. BE should be investigated in prospective trials.

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Reports of Practical Oncology and Radiotherapy