open access

Vol 25, No 2 (2020)
Original research articles
Published online: 2020-03-01
Submitted: 2019-01-28
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Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats

Fatemeh Kadivar, Gholamhassan Haddadi, Mohammad Amin Mosleh-Shirazi, Fatemeh Khajeh, Alireza Tavasoli
DOI: 10.1016/j.rpor.2019.12.023
·
Rep Pract Oncol Radiother 2020;25(2):206-211.

open access

Vol 25, No 2 (2020)
Original research articles
Published online: 2020-03-01
Submitted: 2019-01-28

Abstract

Introduction

Radiation therapy is one of the most common tools for treating cancer. The aim is to deliver adequate doses of radiation to kill cancer cells and the most challenging part during this procedure is to protect normal cells from radiation. One strategy is to use a radioprotector to spare normal tissues from ionizing radiation effects. Researchers have pursued cerium oxide nanoparticles as a therapeutic agent, due to its diverse characteristics, which include antioxidant properties, making it a potential radioprotector.

Materials and methods

One hundred rats were divided into five groups of A) control group, intraperitoneal (IP) saline injection was done twice a week; B) bi-weekly IP injection of 14.5nM (0.00001mg/kg) CNP for two weeks; C) a single whole thorax radiation dose of 18Gy; D) a single whole thorax radiation dose of 18Gy+bi-weekly injection of 14.5nM CNP for two weeks after radiation; E) bi-weekly IP injection of 14.5nM CNP for two weeks prior to radiation+a single whole thorax radiation dose of 18Gy. Thirty days after irradiation, 7 rats from each group were anesthetized and their lungs extracted for histopathological examination.

Results

Statistical analyses revealed that CNP significantly decreased the incidence of tissue collapse and neutrophile aggregation in rats receiving CNP before radiation in comparison with the radiation group.

Conclusion

The results suggested the possibility of using CNP as a future radioprotector due to its ability to protect normal cells against radiation-induced damage.

Abstract

Introduction

Radiation therapy is one of the most common tools for treating cancer. The aim is to deliver adequate doses of radiation to kill cancer cells and the most challenging part during this procedure is to protect normal cells from radiation. One strategy is to use a radioprotector to spare normal tissues from ionizing radiation effects. Researchers have pursued cerium oxide nanoparticles as a therapeutic agent, due to its diverse characteristics, which include antioxidant properties, making it a potential radioprotector.

Materials and methods

One hundred rats were divided into five groups of A) control group, intraperitoneal (IP) saline injection was done twice a week; B) bi-weekly IP injection of 14.5nM (0.00001mg/kg) CNP for two weeks; C) a single whole thorax radiation dose of 18Gy; D) a single whole thorax radiation dose of 18Gy+bi-weekly injection of 14.5nM CNP for two weeks after radiation; E) bi-weekly IP injection of 14.5nM CNP for two weeks prior to radiation+a single whole thorax radiation dose of 18Gy. Thirty days after irradiation, 7 rats from each group were anesthetized and their lungs extracted for histopathological examination.

Results

Statistical analyses revealed that CNP significantly decreased the incidence of tissue collapse and neutrophile aggregation in rats receiving CNP before radiation in comparison with the radiation group.

Conclusion

The results suggested the possibility of using CNP as a future radioprotector due to its ability to protect normal cells against radiation-induced damage.

Get Citation

Keywords

Radiation; Cerium oxide nanoparticle; Lung

About this article
Title

Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 2 (2020)

Pages

206-211

Published online

2020-03-01

DOI

10.1016/j.rpor.2019.12.023

Bibliographic record

Rep Pract Oncol Radiother 2020;25(2):206-211.

Keywords

Radiation
Cerium oxide nanoparticle
Lung

Authors

Fatemeh Kadivar
Gholamhassan Haddadi
Mohammad Amin Mosleh-Shirazi
Fatemeh Khajeh
Alireza Tavasoli

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