open access

Vol 25, No 1 (2020)
Original research articles
Published online: 2020-01-01
Submitted: 2019-04-11
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Normal tissue sparing using different techniques for prostate irradiation

Barbara Melles-Bencsik, Tamás Pócza, Tibor Major, Péter Ágoston, Kliton Jorgo, Csaba Polgár, Csilla Pesznyák
DOI: 10.1016/j.rpor.2019.11.001
·
Rep Pract Oncol Radiother 2020;25(1):85-90.

open access

Vol 25, No 1 (2020)
Original research articles
Published online: 2020-01-01
Submitted: 2019-04-11

Abstract

Aim

The aim of this study was to investigate normal tissue sparing through dosimetric parameters of normal tissue volumes using different irradiation techniques for conventional (CFRT) and simultaneously integrated boost (SIB) schedules.

Background

Several dose-escalation studies for localized prostate cancer (PCa) have shown advanced biochemical relapse-free (bRFS) rates and also better local control for higher total doses using either CFRT or SIB schedules. Besides the most important organs-at-risk, absorbed dose reduction of other surrounding normal tissues are also preferable. In order to analyse the normal tissue sparing, dosimetric parameters of different normal tissue volumes were examined.

Materials and methods

Treatment plans for 15 high risk prostate cancer patients were created using RapidArc (RA), Sliding Window (SW) IMRT and 4-field box (3D-CRT) technique. In order to evaluate normal tissue sparing, the volume of pelvic region was divided into six normal tissue cylinders with 1cm wall thickness, located in each other.

Results

All plans met the criteria of target coverage (V95%>95%). All techniques provided the same results for OARs except 3D-CRT for rectum and bilateral femoral heads. The values of V5, V10 and V15 increased in cases which included RapidArc technique and decreased for V20 and V30.

Conclusions

The dosimetric parameters for the cylindrical normal tissue volumes show that using RapidArc technique gives equal or slightly better normal tissue sparing and SIB provided the same normal tissue sparing as CFRT planned with RapidArc.

Abstract

Aim

The aim of this study was to investigate normal tissue sparing through dosimetric parameters of normal tissue volumes using different irradiation techniques for conventional (CFRT) and simultaneously integrated boost (SIB) schedules.

Background

Several dose-escalation studies for localized prostate cancer (PCa) have shown advanced biochemical relapse-free (bRFS) rates and also better local control for higher total doses using either CFRT or SIB schedules. Besides the most important organs-at-risk, absorbed dose reduction of other surrounding normal tissues are also preferable. In order to analyse the normal tissue sparing, dosimetric parameters of different normal tissue volumes were examined.

Materials and methods

Treatment plans for 15 high risk prostate cancer patients were created using RapidArc (RA), Sliding Window (SW) IMRT and 4-field box (3D-CRT) technique. In order to evaluate normal tissue sparing, the volume of pelvic region was divided into six normal tissue cylinders with 1cm wall thickness, located in each other.

Results

All plans met the criteria of target coverage (V95%>95%). All techniques provided the same results for OARs except 3D-CRT for rectum and bilateral femoral heads. The values of V5, V10 and V15 increased in cases which included RapidArc technique and decreased for V20 and V30.

Conclusions

The dosimetric parameters for the cylindrical normal tissue volumes show that using RapidArc technique gives equal or slightly better normal tissue sparing and SIB provided the same normal tissue sparing as CFRT planned with RapidArc.

Get Citation

Keywords

Prostate cancer; Radiotherapy; Simultaneously integrated boost; Normal tissue sparing

About this article
Title

Normal tissue sparing using different techniques for prostate irradiation

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 1 (2020)

Pages

85-90

Published online

2020-01-01

DOI

10.1016/j.rpor.2019.11.001

Bibliographic record

Rep Pract Oncol Radiother 2020;25(1):85-90.

Keywords

Prostate cancer
Radiotherapy
Simultaneously integrated boost
Normal tissue sparing

Authors

Barbara Melles-Bencsik
Tamás Pócza
Tibor Major
Péter Ágoston
Kliton Jorgo
Csaba Polgár
Csilla Pesznyák

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