open access

Vol 25, No 1 (2020)
Original research articles
Published online: 2020-01-01
Submitted: 2019-05-30
Get Citation

Determination of inflection points of CyberKnife dose profiles within acceptability criteria of deviations in measurements

Neslihan Sarıgül, Fazlı Yağız Yedekçi, Mete Yeğiner, Fadıl Akyol, Haluk Utku
DOI: 10.1016/j.rpor.2019.10.008
·
Rep Pract Oncol Radiother 2020;25(1):6-12.

open access

Vol 25, No 1 (2020)
Original research articles
Published online: 2020-01-01
Submitted: 2019-05-30

Abstract

Aim

The aim of this study was to determine the Inflection Points (IPs) of flattening filter free (FFF) CyberKnife dose profiles for cone-based streotactic radiotherapy. In addition, dosimetric field sizes were determined.

Background

The increased need for treatment in the early stages of cancer necessitated the treatment of smaller tumors. However, efforts in that direction required the modeling accuracy of the beam. Removal of the flattening filter (FF) from the path of x-ray beam has provided the solution to those efforts, but required a different normalization approach for the beam to ensure the delivery of the dose accurately. As a solution, researchers proposed a normalization factor based on IPs.

Materials and methods

Measurements using microDiamond (PTW 60019), Diode SRS (PTW 60018) and Monte Carlo (MC) calculations of dose profiles were completed at SAD 80cm and 5cm depth for 15–60mm cones. Performance analysis of detectors with respect to MC calculation was carried out. Gamma evaluation method was used to determine achievable acceptability criteria for FFF CyberKnife beams.

Results

Acceptability within (3%–0.5mm) was found to be anachievable criterion for all dose profile measurements of the cone beams used in this study. To determine the IP, the first and second derivatives of the dose profile were determined via the cubic spline interpolation technique.

Conclusion

Derivatives of the interpolated profiles showed that locations of IPs and 50% isodose points coincide.

Abstract

Aim

The aim of this study was to determine the Inflection Points (IPs) of flattening filter free (FFF) CyberKnife dose profiles for cone-based streotactic radiotherapy. In addition, dosimetric field sizes were determined.

Background

The increased need for treatment in the early stages of cancer necessitated the treatment of smaller tumors. However, efforts in that direction required the modeling accuracy of the beam. Removal of the flattening filter (FF) from the path of x-ray beam has provided the solution to those efforts, but required a different normalization approach for the beam to ensure the delivery of the dose accurately. As a solution, researchers proposed a normalization factor based on IPs.

Materials and methods

Measurements using microDiamond (PTW 60019), Diode SRS (PTW 60018) and Monte Carlo (MC) calculations of dose profiles were completed at SAD 80cm and 5cm depth for 15–60mm cones. Performance analysis of detectors with respect to MC calculation was carried out. Gamma evaluation method was used to determine achievable acceptability criteria for FFF CyberKnife beams.

Results

Acceptability within (3%–0.5mm) was found to be anachievable criterion for all dose profile measurements of the cone beams used in this study. To determine the IP, the first and second derivatives of the dose profile were determined via the cubic spline interpolation technique.

Conclusion

Derivatives of the interpolated profiles showed that locations of IPs and 50% isodose points coincide.

Get Citation

Keywords

Inflection Point; Gamma evaluation; Dosimetric field size; CyberKnife

About this article
Title

Determination of inflection points of CyberKnife dose profiles within acceptability criteria of deviations in measurements

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 25, No 1 (2020)

Pages

6-12

Published online

2020-01-01

DOI

10.1016/j.rpor.2019.10.008

Bibliographic record

Rep Pract Oncol Radiother 2020;25(1):6-12.

Keywords

Inflection Point
Gamma evaluation
Dosimetric field size
CyberKnife

Authors

Neslihan Sarıgül
Fazlı Yağız Yedekçi
Mete Yeğiner
Fadıl Akyol
Haluk Utku

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