open access

Vol 24, No 6 (2019)
Original research articles
Published online: 2019-11-01
Submitted: 2019-01-17
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Changes in lung volume parameters regarding the received dose in the lobes of the lungs after locoregional radiotherapy of breast cancer

Mahsa Abdemanafi, Mohammad Bagher Tavakoli, Ali Akhavan, Iraj Abedi
DOI: 10.1016/j.rpor.2019.09.005
·
Rep Pract Oncol Radiother 2019;24(6):556-562.

open access

Vol 24, No 6 (2019)
Original research articles
Published online: 2019-11-01
Submitted: 2019-01-17

Abstract

Aim

The purpose of this study was to evaluate ΔLVP11Changes in lung volume parameters and correlate them with MLD22Mean lung dose and V2033The percentage of lung volume receiving 20 Gy in the lobes of the lung.

Background

Radiation-induced lung injury after breast irradiation is controversial. The incidence of such an injury could have negative consequences on breast cancer patients.

Materials and Methods

Twenty-three women treated with Breast-conserving surgery, chemotherapy, and locoregional RT44Radiation therapy underwent body plethysmography pre-RT and 3 and 6 months post-RT. Statistical analysis was used to evaluate ΔLVP over time and relate them with MLD, V20, age, and concurrent hormonal therapy.

Results

LVP decreased after 3 months and then showed a slight improvement by returning partially to their pre-RT values after 6 months. The mean ΔLVP was −0.64% for one Gy increase of MLD and −0.34% for one percent increase of V20 after 3 months. After 6 months, only ΔVC55Vital Capacity showed 0.45% reduction with MLD in the upper lobe. Finally, there was no significant correlation between ΔLVP with respect to age and concurrent hormonal therapy.

Conclusions

The results of this study showed that lung volume changes were not a cause for concern in breast cancer patients. There are three reasons to support this conclusion. Lung volume changes and percentage reductions in LVP for each Gy increase of MLD and each percentage increase of V20 in each lobe were small; patients were asymptomatic during the follow-up period; and LVP showed partial improvements after 6 months.

Abstract

Aim

The purpose of this study was to evaluate ΔLVP11Changes in lung volume parameters and correlate them with MLD22Mean lung dose and V2033The percentage of lung volume receiving 20 Gy in the lobes of the lung.

Background

Radiation-induced lung injury after breast irradiation is controversial. The incidence of such an injury could have negative consequences on breast cancer patients.

Materials and Methods

Twenty-three women treated with Breast-conserving surgery, chemotherapy, and locoregional RT44Radiation therapy underwent body plethysmography pre-RT and 3 and 6 months post-RT. Statistical analysis was used to evaluate ΔLVP over time and relate them with MLD, V20, age, and concurrent hormonal therapy.

Results

LVP decreased after 3 months and then showed a slight improvement by returning partially to their pre-RT values after 6 months. The mean ΔLVP was −0.64% for one Gy increase of MLD and −0.34% for one percent increase of V20 after 3 months. After 6 months, only ΔVC55Vital Capacity showed 0.45% reduction with MLD in the upper lobe. Finally, there was no significant correlation between ΔLVP with respect to age and concurrent hormonal therapy.

Conclusions

The results of this study showed that lung volume changes were not a cause for concern in breast cancer patients. There are three reasons to support this conclusion. Lung volume changes and percentage reductions in LVP for each Gy increase of MLD and each percentage increase of V20 in each lobe were small; patients were asymptomatic during the follow-up period; and LVP showed partial improvements after 6 months.

Get Citation

Keywords

Lung volume parameters; Received dose; Lobes of the lungs; Loco-regional radiotherapy; Breast cancer

About this article
Title

Changes in lung volume parameters regarding the received dose in the lobes of the lungs after locoregional radiotherapy of breast cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 6 (2019)

Pages

556-562

Published online

2019-11-01

DOI

10.1016/j.rpor.2019.09.005

Bibliographic record

Rep Pract Oncol Radiother 2019;24(6):556-562.

Keywords

Lung volume parameters
Received dose
Lobes of the lungs
Loco-regional radiotherapy
Breast cancer

Authors

Mahsa Abdemanafi
Mohammad Bagher Tavakoli
Ali Akhavan
Iraj Abedi

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