open access

Vol 24, No 6 (2019)
Original research articles
Published online: 2019-11-01
Submitted: 2019-05-05
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Intraoperative breast radiotherapy: survival, local control and risk factors for recurrence

Guilherme Rocha Gondim, Fabiana Baroni Makdissi, Ricardo Cesar Fogaroli, Juan Bautista Collins, Hirofumi Iyeyasu, Douglas Guedes de Castro, Maria Letícia Silva, Michael Jenwei Chen, Tharcisio Machado Coelho, Henderson Ramos, Antônio Cássio Pellizzon
DOI: 10.1016/j.rpor.2019.09.004
·
Rep Pract Oncol Radiother 2019;24(6):551-555.

open access

Vol 24, No 6 (2019)
Original research articles
Published online: 2019-11-01
Submitted: 2019-05-05

Abstract

Background

Whole breast irradiation reduces loco-regional recurrence and risk of death in patients submitted to breast-conserving treatment. Data show that radiation to the index quadrant alone may be enough in selected patients.

Aim

To report the experience with intra-operative radiotherapy (IORT) with Electron-beam Cone in Linear Accelerator (ELIOT) and the results in overall survival, local control and late toxicity of patients submitted to this treatment.

Materials and Methods

147 patients treated with a median follow up of 6.9 years (0.1⿿11.5 years). The actuarial local control and overall survival probabilities were estimated using the Kaplan Meier method. All tests were two-sided and p⿤0.05 was considered statistically significant.

Results

Overall survival of the cohort in 5 years, in the median follow up and in 10 years was of 98.3%, 95.1% and 95.1%, respectively, whereas local control in 5 years, in the median follow up and in 10 years was of 96%, 94.9% and 89.5%, respectively. Two risk groups were identified for local recurrence depending on the estrogen or progesterone receptors, axillary or margin status and lymphovascular invasion (LVI) (p=0.016).

Conclusions

IORT is a safe and effective treatment. Rigorous selection is important to achieve excellent local control results.

Abstract

Background

Whole breast irradiation reduces loco-regional recurrence and risk of death in patients submitted to breast-conserving treatment. Data show that radiation to the index quadrant alone may be enough in selected patients.

Aim

To report the experience with intra-operative radiotherapy (IORT) with Electron-beam Cone in Linear Accelerator (ELIOT) and the results in overall survival, local control and late toxicity of patients submitted to this treatment.

Materials and Methods

147 patients treated with a median follow up of 6.9 years (0.1⿿11.5 years). The actuarial local control and overall survival probabilities were estimated using the Kaplan Meier method. All tests were two-sided and p⿤0.05 was considered statistically significant.

Results

Overall survival of the cohort in 5 years, in the median follow up and in 10 years was of 98.3%, 95.1% and 95.1%, respectively, whereas local control in 5 years, in the median follow up and in 10 years was of 96%, 94.9% and 89.5%, respectively. Two risk groups were identified for local recurrence depending on the estrogen or progesterone receptors, axillary or margin status and lymphovascular invasion (LVI) (p=0.016).

Conclusions

IORT is a safe and effective treatment. Rigorous selection is important to achieve excellent local control results.

Get Citation

Keywords

Breast cancer; Intraoperative radiotherapy; Radiation oncology

About this article
Title

Intraoperative breast radiotherapy: survival, local control and risk factors for recurrence

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 6 (2019)

Pages

551-555

Published online

2019-11-01

DOI

10.1016/j.rpor.2019.09.004

Bibliographic record

Rep Pract Oncol Radiother 2019;24(6):551-555.

Keywords

Breast cancer
Intraoperative radiotherapy
Radiation oncology

Authors

Guilherme Rocha Gondim
Fabiana Baroni Makdissi
Ricardo Cesar Fogaroli
Juan Bautista Collins
Hirofumi Iyeyasu
Douglas Guedes de Castro
Maria Letícia Silva
Michael Jenwei Chen
Tharcisio Machado Coelho
Henderson Ramos
Antônio Cássio Pellizzon

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