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Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies
open access
Abstract
Over the past two decades nanotechnology has become an important part of novel medical research. Researchers have made great progress in developing nanotechnology applications used for detecting and treating oncological diseases. Recently, many research groups have focused on the use of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer treatment. Due to the range of therapeutic properties and possibilities of various modifications, SPIONs are a promising and multifunctional tool in various cancer therapies and may help to overcome the limitations of conventional therapies. Moreover, it is still necessary to develop new methods of treatment with expected properties, such as lower toxicity, long-lasting effectiveness and higher selectivity. Analyzing the literature data, we found that currently SPIONs are used in the transport of drugs, immunotherapy and hyperthermia. The main aim of this review is to present various cancer treatment therapies utilizing SPIONs, the importance of the experiments carried out by research groups and further perspectives in the nanotechnological use of SPIONs.
Abstract
Over the past two decades nanotechnology has become an important part of novel medical research. Researchers have made great progress in developing nanotechnology applications used for detecting and treating oncological diseases. Recently, many research groups have focused on the use of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer treatment. Due to the range of therapeutic properties and possibilities of various modifications, SPIONs are a promising and multifunctional tool in various cancer therapies and may help to overcome the limitations of conventional therapies. Moreover, it is still necessary to develop new methods of treatment with expected properties, such as lower toxicity, long-lasting effectiveness and higher selectivity. Analyzing the literature data, we found that currently SPIONs are used in the transport of drugs, immunotherapy and hyperthermia. The main aim of this review is to present various cancer treatment therapies utilizing SPIONs, the importance of the experiments carried out by research groups and further perspectives in the nanotechnological use of SPIONs.
Keywords
Superparamagnetic iron oxide nanoparticles; Oncology; Nanotechnology; Cancer therapy
About this articleTitle
Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
307-314
Published online
2019-07-01
DOI
10.1016/j.rpor.2019.04.002
Bibliographic record
Rep Pract Oncol Radiother 2019;24(4):307-314.
Keywords
Superparamagnetic iron oxide nanoparticles
Oncology
Nanotechnology
Cancer therapy
Authors
Marika Musielak
Igor Piotrowski
Wiktoria M. Suchorska