open access

Vol 24, No 4 (2019)
Reviews
Published online: 2019-07-01
Submitted: 2018-10-29
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Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies

Marika Musielak, Igor Piotrowski, Wiktoria M. Suchorska
DOI: 10.1016/j.rpor.2019.04.002
·
Rep Pract Oncol Radiother 2019;24(4):307-314.

open access

Vol 24, No 4 (2019)
Reviews
Published online: 2019-07-01
Submitted: 2018-10-29

Abstract

Over the past two decades nanotechnology has become an important part of novel medical research. Researchers have made great progress in developing nanotechnology applications used for detecting and treating oncological diseases. Recently, many research groups have focused on the use of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer treatment. Due to the range of therapeutic properties and possibilities of various modifications, SPIONs are a promising and multifunctional tool in various cancer therapies and may help to overcome the limitations of conventional therapies. Moreover, it is still necessary to develop new methods of treatment with expected properties, such as lower toxicity, long-lasting effectiveness and higher selectivity. Analyzing the literature data, we found that currently SPIONs are used in the transport of drugs, immunotherapy and hyperthermia. The main aim of this review is to present various cancer treatment therapies utilizing SPIONs, the importance of the experiments carried out by research groups and further perspectives in the nanotechnological use of SPIONs.

Abstract

Over the past two decades nanotechnology has become an important part of novel medical research. Researchers have made great progress in developing nanotechnology applications used for detecting and treating oncological diseases. Recently, many research groups have focused on the use of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer treatment. Due to the range of therapeutic properties and possibilities of various modifications, SPIONs are a promising and multifunctional tool in various cancer therapies and may help to overcome the limitations of conventional therapies. Moreover, it is still necessary to develop new methods of treatment with expected properties, such as lower toxicity, long-lasting effectiveness and higher selectivity. Analyzing the literature data, we found that currently SPIONs are used in the transport of drugs, immunotherapy and hyperthermia. The main aim of this review is to present various cancer treatment therapies utilizing SPIONs, the importance of the experiments carried out by research groups and further perspectives in the nanotechnological use of SPIONs.

Get Citation

Keywords

Superparamagnetic iron oxide nanoparticles; Oncology; Nanotechnology; Cancer therapy

About this article
Title

Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 4 (2019)

Pages

307-314

Published online

2019-07-01

DOI

10.1016/j.rpor.2019.04.002

Bibliographic record

Rep Pract Oncol Radiother 2019;24(4):307-314.

Keywords

Superparamagnetic iron oxide nanoparticles
Oncology
Nanotechnology
Cancer therapy

Authors

Marika Musielak
Igor Piotrowski
Wiktoria M. Suchorska

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