open access

Vol 24, No 4 (2019)
Original research articles
Published online: 2019-07-01
Submitted: 2018-10-23
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Pre-radiotherapy daily exercise training in non-small cell lung cancer: A feasibility study

Trine Egegaard, Julie Rohold, Christian Lillelund, Gitte Persson, Morten Quist
DOI: 10.1016/j.rpor.2019.06.003
·
Rep Pract Oncol Radiother 2019;24(4):375-382.

open access

Vol 24, No 4 (2019)
Original research articles
Published online: 2019-07-01
Submitted: 2018-10-23

Abstract

Aim

To examine the feasibility of an individual, supervised, structured moderate-to-high intensity cycle ergometer exercise training immediately before radiotherapy in patients undergoing concomitant chemoradiotherapy for locally advanced non-small cell lung cancer (NSCLC).

Background

Lung cancer is the most common form of cancer. Despite significant advancements in therapy and supportive care it is still the leading cause of cancer-related death worldwide.

Materials and methods

Randomized controlled study design; patients with NSCLC receiving concomitant chemoradiotherapy were recruited and randomly assigned to either the exercise (EXE) or the control (CON) group. Exercise training consisted of 20min moderate-to-high intensity aerobic interval training 5 times per week (Mon–Fri) prior to radiotherapy. Secondary outcomes were assessed at baseline and after 7 weeks: peak oxygen consumption (VO2peak), functional capacity (6MWD), pulmonary function (FEV1), psychosocial parameters (quality of life (FACT-L), anxiety and depression (HADS)) and cancer-related side effects (reported daily).

Results

Fifteen patients were included. All patients completed a baseline test, while 13 patients were eligible for a posttest. The recruiting rate was 44.1% and the overall attendance rate to exercise was 90.0% with an adherence rate to full exercise participation of 88.1%. No adverse events or any unexpected reactions were observed during the exercise sessions. No significant differences were observed within or between groups from baseline to post intervention in any of the secondary outcomes.

Conclusion

This study demonstrated ‘proof of principle’ that daily moderate-to-high intensity cycle ergometer exercise was feasible, safe and well tolerated among newly diagnosed patients with locally advanced NSCLC undergoing concomitant chemoradiotherapy. Larger randomized controlled trials are warranted.

Abstract

Aim

To examine the feasibility of an individual, supervised, structured moderate-to-high intensity cycle ergometer exercise training immediately before radiotherapy in patients undergoing concomitant chemoradiotherapy for locally advanced non-small cell lung cancer (NSCLC).

Background

Lung cancer is the most common form of cancer. Despite significant advancements in therapy and supportive care it is still the leading cause of cancer-related death worldwide.

Materials and methods

Randomized controlled study design; patients with NSCLC receiving concomitant chemoradiotherapy were recruited and randomly assigned to either the exercise (EXE) or the control (CON) group. Exercise training consisted of 20min moderate-to-high intensity aerobic interval training 5 times per week (Mon–Fri) prior to radiotherapy. Secondary outcomes were assessed at baseline and after 7 weeks: peak oxygen consumption (VO2peak), functional capacity (6MWD), pulmonary function (FEV1), psychosocial parameters (quality of life (FACT-L), anxiety and depression (HADS)) and cancer-related side effects (reported daily).

Results

Fifteen patients were included. All patients completed a baseline test, while 13 patients were eligible for a posttest. The recruiting rate was 44.1% and the overall attendance rate to exercise was 90.0% with an adherence rate to full exercise participation of 88.1%. No adverse events or any unexpected reactions were observed during the exercise sessions. No significant differences were observed within or between groups from baseline to post intervention in any of the secondary outcomes.

Conclusion

This study demonstrated ‘proof of principle’ that daily moderate-to-high intensity cycle ergometer exercise was feasible, safe and well tolerated among newly diagnosed patients with locally advanced NSCLC undergoing concomitant chemoradiotherapy. Larger randomized controlled trials are warranted.

Get Citation

Keywords

Chemoradiotherapy; Non-small cell lung cancer; Cancer-related-fatigue; VO2peak; 6MWD; Quality of Life

About this article
Title

Pre-radiotherapy daily exercise training in non-small cell lung cancer: A feasibility study

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 4 (2019)

Pages

375-382

Published online

2019-07-01

DOI

10.1016/j.rpor.2019.06.003

Bibliographic record

Rep Pract Oncol Radiother 2019;24(4):375-382.

Keywords

Chemoradiotherapy
Non-small cell lung cancer
Cancer-related-fatigue
VO2peak
6MWD
Quality of Life

Authors

Trine Egegaard
Julie Rohold
Christian Lillelund
Gitte Persson
Morten Quist

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