open access

Vol 24, No 3 (2019)
Original research articles
Published online: 2019-05-01
Submitted: 2018-08-10
Get Citation

Estimation of tumor and local tissue dose in gold nanoparticles radiotherapy for prostate cancer

Amal Y. Al-Yasiri, Nathan E. White, Kattesh V. Katti, Sudarshan K. Loyalka
DOI: 10.1016/j.rpor.2019.02.006
·
Rep Pract Oncol Radiother 2019;24(3):288-293.

open access

Vol 24, No 3 (2019)
Original research articles
Published online: 2019-05-01
Submitted: 2018-08-10

Abstract

Aim

The objective of this research was to estimate the dose distribution delivered by radioactive gold nanoparticles (198AuNPs or 199AuNPs) to the tumor inside the human prostate as well as to normal tissues surrounding the tumor using the Monte-Carlo N-Particle code (MCNP-6.1.1 code).

Background

Radioactive gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated to treat prostate cancer in animals. In order to use them as a new therapeutic modality to treat human prostate cancer, accurate radiation dosimetry simulations are required to estimate the energy deposition in the tumor and surrounding tissue and to establish the course of therapy for the patient.

Materials and methods

A simple geometrical model of a human prostate was used, and the dose deposited by 198AuNPs or 199AuNPs to the tumor within the prostate as well as to the healthy tissue surrounding the prostate was calculated using the MCNP code. Water and A-150 TEP phantoms were used to simulate the soft and tumor tissues.

Results

The results showed that the dose due to 198AuNPs or 199AuNPs, which are distributed homogenously in the tumor, had a maximal value in the tumor region and then rapidly decreased toward the prostate–tumor interface and surrounding organs. However, the dose deposited by 198Au is significantly higher than the dose deposited by 199Au in the tumor region as well as normal tissues.

Conclusions

According to the MCNP results, 198AuNPs are a promising modality to treat prostate cancer and other cancers and 199AuNPs could be used for imaging purposes.

Abstract

Aim

The objective of this research was to estimate the dose distribution delivered by radioactive gold nanoparticles (198AuNPs or 199AuNPs) to the tumor inside the human prostate as well as to normal tissues surrounding the tumor using the Monte-Carlo N-Particle code (MCNP-6.1.1 code).

Background

Radioactive gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated to treat prostate cancer in animals. In order to use them as a new therapeutic modality to treat human prostate cancer, accurate radiation dosimetry simulations are required to estimate the energy deposition in the tumor and surrounding tissue and to establish the course of therapy for the patient.

Materials and methods

A simple geometrical model of a human prostate was used, and the dose deposited by 198AuNPs or 199AuNPs to the tumor within the prostate as well as to the healthy tissue surrounding the prostate was calculated using the MCNP code. Water and A-150 TEP phantoms were used to simulate the soft and tumor tissues.

Results

The results showed that the dose due to 198AuNPs or 199AuNPs, which are distributed homogenously in the tumor, had a maximal value in the tumor region and then rapidly decreased toward the prostate–tumor interface and surrounding organs. However, the dose deposited by 198Au is significantly higher than the dose deposited by 199Au in the tumor region as well as normal tissues.

Conclusions

According to the MCNP results, 198AuNPs are a promising modality to treat prostate cancer and other cancers and 199AuNPs could be used for imaging purposes.

Get Citation

Keywords

Dose distribution; Radioactive gold nanoparticles; Prostate tumor; MCNP

About this article
Title

Estimation of tumor and local tissue dose in gold nanoparticles radiotherapy for prostate cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 3 (2019)

Pages

288-293

Published online

2019-05-01

DOI

10.1016/j.rpor.2019.02.006

Bibliographic record

Rep Pract Oncol Radiother 2019;24(3):288-293.

Keywords

Dose distribution
Radioactive gold nanoparticles
Prostate tumor
MCNP

Authors

Amal Y. Al-Yasiri
Nathan E. White
Kattesh V. Katti
Sudarshan K. Loyalka

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl