open access

Vol 24, No 2 (2019)
Reviews
Published online: 2019-03-01
Submitted: 2018-07-26
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Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines

Jakub Dalibor Rybka
DOI: 10.1016/j.rpor.2019.01.002
·
Rep Pract Oncol Radiother 2019;24(2):152-157.

open access

Vol 24, No 2 (2019)
Reviews
Published online: 2019-03-01
Submitted: 2018-07-26

Abstract

Melanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, which not only enhance radiosensitivity, but also enable precise targeting by exploitation of their magnetic properties.

Abstract

Melanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, which not only enhance radiosensitivity, but also enable precise targeting by exploitation of their magnetic properties.

Get Citation

Keywords

Melanoma; Superparamagnetic iron oxide nanoparticles; Radiosensitization

About this article
Title

Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 2 (2019)

Pages

152-157

Published online

2019-03-01

DOI

10.1016/j.rpor.2019.01.002

Bibliographic record

Rep Pract Oncol Radiother 2019;24(2):152-157.

Keywords

Melanoma
Superparamagnetic iron oxide nanoparticles
Radiosensitization

Authors

Jakub Dalibor Rybka

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