open access

Vol 24, No 1 (2019)
Case reports
Published online: 2019-01-01
Submitted: 2018-05-10
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Association between inflammatory bowel disease and uveal melanoma: case report of two young adults and a literature review

Salvatore Cozzi, Andrea Slocker Escarpa, Daniel Lorenzo Parra, Dina Najjari Jamal, Josep Maria Mitjana, Josep Maria R., Ferran Guedea Edo, Cristina Gutierrez Miguelez
DOI: 10.1016/j.rpor.2018.10.002
·
Rep Pract Oncol Radiother 2019;24(1):56-59.

open access

Vol 24, No 1 (2019)
Case reports
Published online: 2019-01-01
Submitted: 2018-05-10

Abstract

Introduction

Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). A diagnosis of IBD and the use of immunosuppressive drugs are both independently associated with an increased risk of developing skin melanoma. The association between IBD and uveal melanoma (UM) has not been previously described.

Cases description

Two young Caucasian men, aged 24 and 28, developed UM 3 and 15 years, respectively, after being diagnosed with IBD. Both received long-term treatment with immunomodulatory drugs, with periodic switching among the drugs due to the refractory nature of IBD. In both cases, melanoma was treated by brachytherapy with iodine-125 COMS plaque implant at a dose of 75Gy.

Discussion

Chronic inflammation can promote cell proliferation and growth. The use of immunomodulatory drugs is associated with an increased risk of developing melanoma and non-melanoma skin cancer. The two patients described in this report both had long-standing IBD treated with immunomodulatory drugs. It seems reasonable to suggest that these two factors may have promoted the development of uveal melanoma. More studies are warranted to investigate and confirm this possible association.

Abstract

Introduction

Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). A diagnosis of IBD and the use of immunosuppressive drugs are both independently associated with an increased risk of developing skin melanoma. The association between IBD and uveal melanoma (UM) has not been previously described.

Cases description

Two young Caucasian men, aged 24 and 28, developed UM 3 and 15 years, respectively, after being diagnosed with IBD. Both received long-term treatment with immunomodulatory drugs, with periodic switching among the drugs due to the refractory nature of IBD. In both cases, melanoma was treated by brachytherapy with iodine-125 COMS plaque implant at a dose of 75Gy.

Discussion

Chronic inflammation can promote cell proliferation and growth. The use of immunomodulatory drugs is associated with an increased risk of developing melanoma and non-melanoma skin cancer. The two patients described in this report both had long-standing IBD treated with immunomodulatory drugs. It seems reasonable to suggest that these two factors may have promoted the development of uveal melanoma. More studies are warranted to investigate and confirm this possible association.

Get Citation

Keywords

Brachytherapy; Crohn' s disease; IBD; Immunomodulatory drugs; Uveal melanoma; Ulcerative colitis

About this article
Title

Association between inflammatory bowel disease and uveal melanoma: case report of two young adults and a literature review

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 1 (2019)

Pages

56-59

Published online

2019-01-01

DOI

10.1016/j.rpor.2018.10.002

Bibliographic record

Rep Pract Oncol Radiother 2019;24(1):56-59.

Keywords

Brachytherapy
Crohn's disease
IBD
Immunomodulatory drugs
Uveal melanoma
Ulcerative colitis

Authors

Salvatore Cozzi
Andrea Slocker Escarpa
Daniel Lorenzo Parra
Dina Najjari Jamal
Josep Maria Mitjana
Josep Maria R.
Ferran Guedea Edo
Cristina Gutierrez Miguelez

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