open access

Vol 24, No 1 (2019)
Original research articles
Published online: 2019-01-01
Submitted: 2017-10-09
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Estimation of microvascular capillary physical parameters using MRI assuming a pseudo liquid drop as model of fluid exchange on the cellular level

Mansour Ashoor, Abdollah Khorshidi, Leila Sarkhosh
DOI: 10.1016/j.rpor.2018.09.007
·
Rep Pract Oncol Radiother 2019;24(1):3-11.

open access

Vol 24, No 1 (2019)
Original research articles
Published online: 2019-01-01
Submitted: 2017-10-09

Abstract

Aim

One of the most important microvasculatures’ geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined.

Background

Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis.

Methods

To estimate the number of pores, a new pseudo-liquid drop model along with appropriate quantitative physiological purposes has been investigated toward indicating a package of data on the capillary space. This model has utilized the MRI perfusion, diffusion and relaxivity parameters such as cerebral blood volume (CBV), apparent diffusion coefficient (ADC), ΔR2 and [[mml:math altimg="si1.gif"]][[mml:mrow]][[mml:mi]]Δ[[/mml:mi]][[mml:msubsup]][[mml:mi]]R[[/mml:mi]][[mml:mn]]2[[/mml:mn]][[mml:mo]]*[[/mml:mo]][[/mml:msubsup]][[/mml:mrow]][[/mml:math]] values. To verify the model, a special protocol was designed and tested on various regions of eight male Wistar rats.

Results

The maximum number of pores per capillary length in the various conditions such as recovery, core, normal-recovery, and normal-core were found to be 183±146, 176±160, 275±166, and 283±143, respectively. This ratio in the normal regions was more than that of the damaged ones. The number of pores increased with increasing mean radius of the capillary and decreasing the thickness of the wall in the capillary space.

Conclusion

Determination of the number of capillary pore may most likely help to evaluate angiogenesis in the tissues and treatment planning of abnormal ones.

Abstract

Aim

One of the most important microvasculatures’ geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined.

Background

Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis.

Methods

To estimate the number of pores, a new pseudo-liquid drop model along with appropriate quantitative physiological purposes has been investigated toward indicating a package of data on the capillary space. This model has utilized the MRI perfusion, diffusion and relaxivity parameters such as cerebral blood volume (CBV), apparent diffusion coefficient (ADC), ΔR2 and [[mml:math altimg="si1.gif"]][[mml:mrow]][[mml:mi]]Δ[[/mml:mi]][[mml:msubsup]][[mml:mi]]R[[/mml:mi]][[mml:mn]]2[[/mml:mn]][[mml:mo]]*[[/mml:mo]][[/mml:msubsup]][[/mml:mrow]][[/mml:math]] values. To verify the model, a special protocol was designed and tested on various regions of eight male Wistar rats.

Results

The maximum number of pores per capillary length in the various conditions such as recovery, core, normal-recovery, and normal-core were found to be 183±146, 176±160, 275±166, and 283±143, respectively. This ratio in the normal regions was more than that of the damaged ones. The number of pores increased with increasing mean radius of the capillary and decreasing the thickness of the wall in the capillary space.

Conclusion

Determination of the number of capillary pore may most likely help to evaluate angiogenesis in the tissues and treatment planning of abnormal ones.

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Keywords

ADC; CBF; CBV; VSI; TCL; MTT; ROI; MCA; RF; FLASH; DWI; PWI; 2DFT; FOV; Microvasculature; Diffusion MRI; Wistar rats; Diameter; Pores; Pseudo-liquid drop model

About this article
Title

Estimation of microvascular capillary physical parameters using MRI assuming a pseudo liquid drop as model of fluid exchange on the cellular level

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 24, No 1 (2019)

Pages

3-11

Published online

2019-01-01

DOI

10.1016/j.rpor.2018.09.007

Bibliographic record

Rep Pract Oncol Radiother 2019;24(1):3-11.

Keywords

ADC
CBF
CBV
VSI
TCL
MTT
ROI
MCA
RF
FLASH
DWI
PWI
2DFT
FOV
Microvasculature
Diffusion MRI
Wistar rats
Diameter
Pores
Pseudo-liquid drop model

Authors

Mansour Ashoor
Abdollah Khorshidi
Leila Sarkhosh

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