open access

Vol 23, No 6 (2018)
Special Issue Papers
Published online: 2018-11-01
Submitted: 2017-10-31
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Hyperthermia in cervical cancer – current status

Ewa Burchardt, Andrzej Roszak
DOI: 10.1016/j.rpor.2018.05.006
·
Rep Pract Oncol Radiother 2018;23(6):595-603.

open access

Vol 23, No 6 (2018)
Special Issue Papers
Published online: 2018-11-01
Submitted: 2017-10-31

Abstract

Background

This article reviews the salient features of recent results of clinical studies. It puts a special emphasis on technical aspects, mechanisms of action together with radiotherapy and chemotherapy and points out areas for additional investigation.

Aim

To present the current state of knowledge on hyperthermia (HT) and to highlight its role in the treatment of cervical cancer.

Materials and methods

The literature on the clinical use of combined hyperthermia for cervical cancer was analyzed. Clinical outcomes together with the technical aspects and the role of HT were also evaluated.

Results

Clinically randomized trials have demonstrated benefit including survival with the addition of hyperthermia to radiation or chemotherapy in the treatment of cervical cancer without significant acute or late morbidities. The technological advances have led to an effective and safer treatment delivery, thermal treatment planning, thermal dose monitoring and online adaptive temperature modulation.

Conclusions

Due to rapid development over the last decade of hyperthermia systems and new studies at the basic science and clinical level, the perception of hyperthermia as a part of multimodality treatment in cervical cancer has been changed. However, there is still a need for multicentre randomized clinical trials.

Abstract

Background

This article reviews the salient features of recent results of clinical studies. It puts a special emphasis on technical aspects, mechanisms of action together with radiotherapy and chemotherapy and points out areas for additional investigation.

Aim

To present the current state of knowledge on hyperthermia (HT) and to highlight its role in the treatment of cervical cancer.

Materials and methods

The literature on the clinical use of combined hyperthermia for cervical cancer was analyzed. Clinical outcomes together with the technical aspects and the role of HT were also evaluated.

Results

Clinically randomized trials have demonstrated benefit including survival with the addition of hyperthermia to radiation or chemotherapy in the treatment of cervical cancer without significant acute or late morbidities. The technological advances have led to an effective and safer treatment delivery, thermal treatment planning, thermal dose monitoring and online adaptive temperature modulation.

Conclusions

Due to rapid development over the last decade of hyperthermia systems and new studies at the basic science and clinical level, the perception of hyperthermia as a part of multimodality treatment in cervical cancer has been changed. However, there is still a need for multicentre randomized clinical trials.

Get Citation

Keywords

Cervix cancer; Hyperthermia; Radiotherapy; Chemotherapy

About this article
Title

Hyperthermia in cervical cancer – current status

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 6 (2018)

Pages

595-603

Published online

2018-11-01

DOI

10.1016/j.rpor.2018.05.006

Bibliographic record

Rep Pract Oncol Radiother 2018;23(6):595-603.

Keywords

Cervix cancer
Hyperthermia
Radiotherapy
Chemotherapy

Authors

Ewa Burchardt
Andrzej Roszak

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