open access

Vol 23, No 6 (2018)
Special Issue Papers
Published online: 2018-11-01
Submitted: 2017-12-21
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Chemotherapy and molecular therapy in cervical cancer

Gabriela Olivia Regalado Porras, Jessica Chávez Nogueda, Adela Poitevin Chacón
DOI: 10.1016/j.rpor.2018.09.002
·
Rep Pract Oncol Radiother 2018;23(6):533-539.

open access

Vol 23, No 6 (2018)
Special Issue Papers
Published online: 2018-11-01
Submitted: 2017-12-21

Abstract

In recent years, the treatment of locally-advanced and metastatic cervical cancer has improved greatly due to the introduction of targeted therapies, new chemotherapy combinations, and emerging treatments. Candidates for potentially curative treatment are those patients with good functional status without associated comorbidities. Numerous trials have demonstrated that chemotherapy prolongs survival versus supportive care alone. In addition, polychemotherapy schemes are superior to single agent regimens. Targeted molecular agents have proven beneficial in the treatment of cervical cancer. Second-line treatment should be considered standard practice in patients with good functional status. Finally, given the poor survival outcomes in patients with metastatic disease, participation in clinical studies should always be considered the best option.

Abstract

In recent years, the treatment of locally-advanced and metastatic cervical cancer has improved greatly due to the introduction of targeted therapies, new chemotherapy combinations, and emerging treatments. Candidates for potentially curative treatment are those patients with good functional status without associated comorbidities. Numerous trials have demonstrated that chemotherapy prolongs survival versus supportive care alone. In addition, polychemotherapy schemes are superior to single agent regimens. Targeted molecular agents have proven beneficial in the treatment of cervical cancer. Second-line treatment should be considered standard practice in patients with good functional status. Finally, given the poor survival outcomes in patients with metastatic disease, participation in clinical studies should always be considered the best option.

Get Citation

Keywords

Cervical cancer; Systemic therapy; Chemotherapy; Combination; Toxicity; Second primary

About this article
Title

Chemotherapy and molecular therapy in cervical cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 6 (2018)

Pages

533-539

Published online

2018-11-01

DOI

10.1016/j.rpor.2018.09.002

Bibliographic record

Rep Pract Oncol Radiother 2018;23(6):533-539.

Keywords

Cervical cancer
Systemic therapy
Chemotherapy
Combination
Toxicity
Second primary

Authors

Gabriela Olivia Regalado Porras
Jessica Chávez Nogueda
Adela Poitevin Chacón

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