open access

Vol 23, No 4 (2018)
Published online: 2018-07-01
Submitted: 2017-10-23
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Central nervous system metastasis from osteosarcoma: Case report and literature review

María Tereza Nieto-Coronel, Allan David López-Vásquez, Diana Marroquín-Flores, Sandy Ruiz-Cruz, Jorge Luis Martínez-Tláhuel, Jaime De la Garza-Salazar
DOI: 10.1016/j.rpor.2018.06.003
·
Rep Pract Oncol Radiother 2018;23(4):266-269.

open access

Vol 23, No 4 (2018)
Published online: 2018-07-01
Submitted: 2017-10-23

Abstract

Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn’t have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2–6.5%, increase to 10–15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died.

Abstract

Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn’t have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2–6.5%, increase to 10–15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died.

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Keywords

Osteosarcoma; Brain metastasis; Radiation therapy

About this article
Title

Central nervous system metastasis from osteosarcoma: Case report and literature review

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 4 (2018)

Pages

266-269

Published online

2018-07-01

DOI

10.1016/j.rpor.2018.06.003

Bibliographic record

Rep Pract Oncol Radiother 2018;23(4):266-269.

Keywords

Osteosarcoma
Brain metastasis
Radiation therapy

Authors

María Tereza Nieto-Coronel
Allan David López-Vásquez
Diana Marroquín-Flores
Sandy Ruiz-Cruz
Jorge Luis Martínez-Tláhuel
Jaime De la Garza-Salazar

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