open access
Central nervous system metastasis from osteosarcoma: Case report and literature review
open access
Abstract
Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn’t have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2–6.5%, increase to 10–15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died.
Abstract
Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn’t have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2–6.5%, increase to 10–15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died.
Keywords
Osteosarcoma; Brain metastasis; Radiation therapy
About this articleTitle
Central nervous system metastasis from osteosarcoma: Case report and literature review
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
266-269
Published online
2018-07-01
DOI
10.1016/j.rpor.2018.06.003
Bibliographic record
Rep Pract Oncol Radiother 2018;23(4):266-269.
Keywords
Osteosarcoma
Brain metastasis
Radiation therapy
Authors
María Tereza Nieto-Coronel
Allan David López-Vásquez
Diana Marroquín-Flores
Sandy Ruiz-Cruz
Jorge Luis Martínez-Tláhuel
Jaime De la Garza-Salazar