open access

Vol 23, No 3 (2018)
Reviews
Published online: 2018-05-01
Submitted: 2017-11-27
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Application of induced pluripotency in cancer studies

Patrycja Czerwińska, Sylwia Mazurek, Maciej Wiznerowicz
DOI: 10.1016/j.rpor.2018.04.005
·
Rep Pract Oncol Radiother 2018;23(3):207-214.

open access

Vol 23, No 3 (2018)
Reviews
Published online: 2018-05-01
Submitted: 2017-11-27

Abstract

As soon as induced pluripotent stem cells (iPSCs) reprogramming of somatic cells were developed, the discovery attracted the attention of scientists, offering new perspectives for personalized medicine and providing a powerful platform for drug testing. The technology was almost immediately applied to cancer studies. As presented in this review, direct reprogramming of cancer cells with enforced expression of pluripotency factors have several basic purposes, all of which aim to explain the complex nature of cancer development and progression, therapy-resistance and relapse, and ultimately lead to the development of novel anti-cancer therapies. Here, we briefly present recent advances in reprogramming methodologies as well as commonalities between cell reprogramming and carcinogenesis and discuss recent outcomes from the implementation of induced pluripotency into cancer research.

Abstract

As soon as induced pluripotent stem cells (iPSCs) reprogramming of somatic cells were developed, the discovery attracted the attention of scientists, offering new perspectives for personalized medicine and providing a powerful platform for drug testing. The technology was almost immediately applied to cancer studies. As presented in this review, direct reprogramming of cancer cells with enforced expression of pluripotency factors have several basic purposes, all of which aim to explain the complex nature of cancer development and progression, therapy-resistance and relapse, and ultimately lead to the development of novel anti-cancer therapies. Here, we briefly present recent advances in reprogramming methodologies as well as commonalities between cell reprogramming and carcinogenesis and discuss recent outcomes from the implementation of induced pluripotency into cancer research.

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Keywords

CSC; iPSCs; iCSCs; SCNT; Induced pluripotency; Cancer reprogramming; Cancer stem cells

About this article
Title

Application of induced pluripotency in cancer studies

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 3 (2018)

Pages

207-214

Published online

2018-05-01

DOI

10.1016/j.rpor.2018.04.005

Bibliographic record

Rep Pract Oncol Radiother 2018;23(3):207-214.

Keywords

CSC
iPSCs
iCSCs
SCNT
Induced pluripotency
Cancer reprogramming
Cancer stem cells

Authors

Patrycja Czerwińska
Sylwia Mazurek
Maciej Wiznerowicz

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