open access

Vol 23, No 3 (2018)
Reviews
Published online: 2018-05-01
Submitted: 2017-03-20
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Tumor microenvironment – Unknown niche with powerful therapeutic potential

Tomasz Kolenda, Weronika Przybyła, Marta Kapałczyńska, Anna Teresiak, Maria Zajączkowska, Renata Bliźniak, Katarzyna M. Lamperska
DOI: 10.1016/j.rpor.2018.01.004
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Rep Pract Oncol Radiother 2018;23(3):143-153.

open access

Vol 23, No 3 (2018)
Reviews
Published online: 2018-05-01
Submitted: 2017-03-20

Abstract

Head and neck squamous cell carcinomas (HNSCC) are in a group of cancers that are the most resistant to treatment. The survival rate of HNSCC patients has been still very low since last 20 years. The existence of relationship between oncogenic and surrounding cells is probably the reason for a poor response to treatment. Fibroblasts are an important element of tumor stroma which increases tumor cells ability to proliferate. Another highly resistance, tumorigenic and metastatic cell population in tumor microenvironment are cancer initiating cells (CICs). The population of cancer initiating cells can be found regardless of differentiation status of cancer and they seem to be crucial for HNSCC development.

In this review, we describe the current state of knowledge about HNSCC biological and physiological tumor microenvironment.

Abstract

Head and neck squamous cell carcinomas (HNSCC) are in a group of cancers that are the most resistant to treatment. The survival rate of HNSCC patients has been still very low since last 20 years. The existence of relationship between oncogenic and surrounding cells is probably the reason for a poor response to treatment. Fibroblasts are an important element of tumor stroma which increases tumor cells ability to proliferate. Another highly resistance, tumorigenic and metastatic cell population in tumor microenvironment are cancer initiating cells (CICs). The population of cancer initiating cells can be found regardless of differentiation status of cancer and they seem to be crucial for HNSCC development.

In this review, we describe the current state of knowledge about HNSCC biological and physiological tumor microenvironment.

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Keywords

Tumor microenvironment; Tumor initiating cells; Cancer stem cells; Metastasis; Resistance to therapy; HNSCC

About this article
Title

Tumor microenvironment – Unknown niche with powerful therapeutic potential

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 3 (2018)

Pages

143-153

Published online

2018-05-01

DOI

10.1016/j.rpor.2018.01.004

Bibliographic record

Rep Pract Oncol Radiother 2018;23(3):143-153.

Keywords

Tumor microenvironment
Tumor initiating cells
Cancer stem cells
Metastasis
Resistance to therapy
HNSCC

Authors

Tomasz Kolenda
Weronika Przybyła
Marta Kapałczyńska
Anna Teresiak
Maria Zajączkowska
Renata Bliźniak
Katarzyna M. Lamperska

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