open access

Vol 23, No 2 (2018)
Review
Published online: 2018-03-01
Submitted: 2016-11-13
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Adenomas – Genetic factors in colorectal cancer prevention

Kycler Witold, Kubiak Anna, Trojanowski Maciej, Janowski Jakub
DOI: 10.1016/j.rpor.2017.12.003
·
Rep Pract Oncol Radiother 2018;23(2):75-83.

open access

Vol 23, No 2 (2018)
Review
Published online: 2018-03-01
Submitted: 2016-11-13

Abstract

Colorectal cancer is the second most common type of cancer both in Europe and Poland. During the last 30 years more than a 3-fold increase has been observed in Poland due to environmental and genetic factors. Almost all colorectal malignancies are related to the formation and malignant transformation of colorectal dysplasia and adenoma. Efforts aiming to decrease the number of colorectal cancer deaths are focused on the disease early detection. Genetic diagnosis for hereditary syndromes predisposing to colorectal cancer has been developed and is a part of the routine treatment. Most cancers are sporadic. They often develop from polyps in the colon. In addition to the genetic events described in the 1990s, showing the adenoma transformation into carcinoma that has been a prime example of malignant transformation for a long time, there are also other possibilities of neoplastic transformation. The recognition of colorectal cancer risk factors make sense as their nature is lifestyle- and diet-related. In this review paper those risk factors are presented and the prevention of colorectal cancer is discussed taking into account genetic factors.

Abstract

Colorectal cancer is the second most common type of cancer both in Europe and Poland. During the last 30 years more than a 3-fold increase has been observed in Poland due to environmental and genetic factors. Almost all colorectal malignancies are related to the formation and malignant transformation of colorectal dysplasia and adenoma. Efforts aiming to decrease the number of colorectal cancer deaths are focused on the disease early detection. Genetic diagnosis for hereditary syndromes predisposing to colorectal cancer has been developed and is a part of the routine treatment. Most cancers are sporadic. They often develop from polyps in the colon. In addition to the genetic events described in the 1990s, showing the adenoma transformation into carcinoma that has been a prime example of malignant transformation for a long time, there are also other possibilities of neoplastic transformation. The recognition of colorectal cancer risk factors make sense as their nature is lifestyle- and diet-related. In this review paper those risk factors are presented and the prevention of colorectal cancer is discussed taking into account genetic factors.

Get Citation

Keywords

Colorectal adenomas; Colorectal cancer; Genetic risk factors

About this article
Title

Adenomas – Genetic factors in colorectal cancer prevention

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 2 (2018)

Pages

75-83

Published online

2018-03-01

DOI

10.1016/j.rpor.2017.12.003

Bibliographic record

Rep Pract Oncol Radiother 2018;23(2):75-83.

Keywords

Colorectal adenomas
Colorectal cancer
Genetic risk factors

Authors

Kycler Witold
Kubiak Anna
Trojanowski Maciej
Janowski Jakub

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