open access

Vol 23, No 2 (2018)
Original research articles
Published online: 2018-03-01
Submitted: 2017-05-04
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Compliance with bladder protocol during concurrent chemoradiation for cancer of the cervix and its impact on enteritis: A prospective observational study

Sweta Bandanatham, Janaki Manur Gururajachar, Mohan Kumar Somashekar
DOI: 10.1016/j.rpor.2017.12.005
·
Rep Pract Oncol Radiother 2018;23(2):69-74.

open access

Vol 23, No 2 (2018)
Original research articles
Published online: 2018-03-01
Submitted: 2017-05-04

Abstract

Aim

This prospective study aims to assess the compliance with bladder protocol and the correlation with enteritis during pelvic radiation.

Background

Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume especially in the last two weeks due to radiation enteritis and cystitis.

Materials and methods

Histologically proven 35 cervical cancer patients treated with concurrent chemoradiation in a tertiary care center were the subjects of this prospective study. Following CT simulation and after every fraction, patients were asked to void urine in a calibrated urine container and the volume was documented. Patients were assessed for the highest grade of radiation enteritis weekly as per common toxicity criteria. The mean voided urine volume was correlated with the radiation enteritis.

Results

The mean urine volume at planning CT scan was 295.85[[ce:hsp sp="0.25"/]]±[[ce:hsp sp="0.25"/]]300[[ce:hsp sp="0.25"/]]ml (SD) with a range of 75–650. At the end of treatment, it was reduced to 233.14[[ce:hsp sp="0.25"/]]±[[ce:hsp sp="0.25"/]]250[[ce:hsp sp="0.25"/]]ml (range 50–400[[ce:hsp sp="0.25"/]]ml), a reduction by 21% (p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.001). The maximum grade of enteritis was grade I (11%), II (11.4%), III (3–29%) in week 1,2 and 3–5, respectively with a p value of <0.001. A mean urine volume of 230[[ce:hsp sp="0.25"/]]ml was associated with grade III enteritis in the third week.

Conclusions

Urine output volume measured using a calibrated container is a simple, efficient and practical method to monitor bladder distension thereby reducing enteritis in cervical cancer patients treated with concurrent chemoradiation.

Abstract

Aim

This prospective study aims to assess the compliance with bladder protocol and the correlation with enteritis during pelvic radiation.

Background

Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume especially in the last two weeks due to radiation enteritis and cystitis.

Materials and methods

Histologically proven 35 cervical cancer patients treated with concurrent chemoradiation in a tertiary care center were the subjects of this prospective study. Following CT simulation and after every fraction, patients were asked to void urine in a calibrated urine container and the volume was documented. Patients were assessed for the highest grade of radiation enteritis weekly as per common toxicity criteria. The mean voided urine volume was correlated with the radiation enteritis.

Results

The mean urine volume at planning CT scan was 295.85[[ce:hsp sp="0.25"/]]±[[ce:hsp sp="0.25"/]]300[[ce:hsp sp="0.25"/]]ml (SD) with a range of 75–650. At the end of treatment, it was reduced to 233.14[[ce:hsp sp="0.25"/]]±[[ce:hsp sp="0.25"/]]250[[ce:hsp sp="0.25"/]]ml (range 50–400[[ce:hsp sp="0.25"/]]ml), a reduction by 21% (p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.001). The maximum grade of enteritis was grade I (11%), II (11.4%), III (3–29%) in week 1,2 and 3–5, respectively with a p value of <0.001. A mean urine volume of 230[[ce:hsp sp="0.25"/]]ml was associated with grade III enteritis in the third week.

Conclusions

Urine output volume measured using a calibrated container is a simple, efficient and practical method to monitor bladder distension thereby reducing enteritis in cervical cancer patients treated with concurrent chemoradiation.

Get Citation

Keywords

Bladder protocol; Enteritis; Cervical cancer

About this article
Title

Compliance with bladder protocol during concurrent chemoradiation for cancer of the cervix and its impact on enteritis: A prospective observational study

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 23, No 2 (2018)

Pages

69-74

Published online

2018-03-01

DOI

10.1016/j.rpor.2017.12.005

Bibliographic record

Rep Pract Oncol Radiother 2018;23(2):69-74.

Keywords

Bladder protocol
Enteritis
Cervical cancer

Authors

Sweta Bandanatham
Janaki Manur Gururajachar
Mohan Kumar Somashekar

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