open access

Vol 22, No 6 (2017)
Published online: 2017-11-01
Submitted: 2016-10-10
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Cyberknife stereotactic radiosurgery and denosumab for giant cell tumour of the skull base: Case report

Cuauhtemoc de la Peña, Jorge H. Guajardo, Maria F. Gonzalez, Miguel A. Hinojosa, Erick Cardona
DOI: 10.1016/j.rpor.2017.08.002
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Rep Pract Oncol Radiother 2017;22(6):429-433.

open access

Vol 22, No 6 (2017)
Published online: 2017-11-01
Submitted: 2016-10-10

Abstract

Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body. The patient received Cyberknife stereotactic radiosurgery (CK SRS) and denosumab after surgery. This combined therapy allowed local control and tumour reduction with secondary neurological improvement during a 4-year follow up.

Abstract

Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body. The patient received Cyberknife stereotactic radiosurgery (CK SRS) and denosumab after surgery. This combined therapy allowed local control and tumour reduction with secondary neurological improvement during a 4-year follow up.

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Keywords

Cyberknife; Stereotactic radiosurgery; Denosumab; Giant cell tumour; Skull base

About this article
Title

Cyberknife stereotactic radiosurgery and denosumab for giant cell tumour of the skull base: Case report

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 22, No 6 (2017)

Pages

429-433

Published online

2017-11-01

DOI

10.1016/j.rpor.2017.08.002

Bibliographic record

Rep Pract Oncol Radiother 2017;22(6):429-433.

Keywords

Cyberknife
Stereotactic radiosurgery
Denosumab
Giant cell tumour
Skull base

Authors

Cuauhtemoc de la Peña
Jorge H. Guajardo
Maria F. Gonzalez
Miguel A. Hinojosa
Erick Cardona

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