open access

Vol 22, No 6 (2017)
Original research articles
Published online: 2017-11-01
Submitted: 2017-04-08
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Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone

Hidekazu Tanaka, Takahiro Yamaguchi, Kae Hachiya, Masahide Hayashi, Shinichi Ogawa, Hironori Nishibori, Shingo Kamei, Satoshi Ishihara, Masayuki Matsuo
DOI: 10.1016/j.rpor.2017.08.009
·
Rep Pract Oncol Radiother 2017;22(6):477-481.

open access

Vol 22, No 6 (2017)
Original research articles
Published online: 2017-11-01
Submitted: 2017-04-08

Abstract

Aim

To assess the changes in prostate size in patients with prostate cancer undergoing intensity-modulated radiation therapy (IMRT).

Background

The effect of size change produced by IMRT is not well known.

Materials and methods

We enrolled 72 patients who received IMRT alone without androgen-deprivation therapy and underwent magnetic resonance imaging (MRI) examination before and after IMRT. The diameter of the entire prostate in the anterior–posterior (P-AP) and left–right (P-LR) directions was measured. The transitional zone diameter in the anterior–posterior (T-AP) and left–right (T-LR) directions was also measured.

Results

The average relative P-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.94, 0.90, 0.89, 0.89, and 0.90, respectively; the average relative P-LR values were 0.93, 0.92, 0.91, 0.91, and 0.90, respectively. The average P-AP and P-LR decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. The average relative T-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.93, 0.88, 0.91, 0.87, and 0.89, respectively; the average relative T-LR values were 0.96, 0.90, 0.91, 0.87, and 0.88, respectively. The average T-AP and T-LR also decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. At 12 months after IMRT, the average relative T-AP was significantly lower in patients with recurrence than in those without recurrence.

Conclusions

The average prostate diameter decreased by approximately 10% during the 12 months after IMRT; thereafter remained unchanged.

Abstract

Aim

To assess the changes in prostate size in patients with prostate cancer undergoing intensity-modulated radiation therapy (IMRT).

Background

The effect of size change produced by IMRT is not well known.

Materials and methods

We enrolled 72 patients who received IMRT alone without androgen-deprivation therapy and underwent magnetic resonance imaging (MRI) examination before and after IMRT. The diameter of the entire prostate in the anterior–posterior (P-AP) and left–right (P-LR) directions was measured. The transitional zone diameter in the anterior–posterior (T-AP) and left–right (T-LR) directions was also measured.

Results

The average relative P-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.94, 0.90, 0.89, 0.89, and 0.90, respectively; the average relative P-LR values were 0.93, 0.92, 0.91, 0.91, and 0.90, respectively. The average P-AP and P-LR decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. The average relative T-AP values at 3, 6, 12, 24, and 36 months after IMRT compared to the pre-IMRT value were 0.93, 0.88, 0.91, 0.87, and 0.89, respectively; the average relative T-LR values were 0.96, 0.90, 0.91, 0.87, and 0.88, respectively. The average T-AP and T-LR also decreased by approximately 10% during the 12 months post-IMRT, and remained unchanged thereafter. At 12 months after IMRT, the average relative T-AP was significantly lower in patients with recurrence than in those without recurrence.

Conclusions

The average prostate diameter decreased by approximately 10% during the 12 months after IMRT; thereafter remained unchanged.

Get Citation

Keywords

Prostate cancer; Intensity-modulated radiation therapy; External beam radiation therapy; Magnetic resonance imaging

About this article
Title

Does intensity-modulated radiation therapy (IMRT) alter prostate size? Magnetic resonance imaging evaluation of patients undergoing IMRT alone

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 22, No 6 (2017)

Pages

477-481

Published online

2017-11-01

DOI

10.1016/j.rpor.2017.08.009

Bibliographic record

Rep Pract Oncol Radiother 2017;22(6):477-481.

Keywords

Prostate cancer
Intensity-modulated radiation therapy
External beam radiation therapy
Magnetic resonance imaging

Authors

Hidekazu Tanaka
Takahiro Yamaguchi
Kae Hachiya
Masahide Hayashi
Shinichi Ogawa
Hironori Nishibori
Shingo Kamei
Satoshi Ishihara
Masayuki Matsuo

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