A comparison of concurrent cisplatin versus cetuximab with radiotherapy in locally-advanced head and neck cancer: A bi-institutional analysis
Abstract
Aim
To present our experience comparing cisplatin- and cetuximab-based radiotherapy for locally-advanced head and neck squamous cell carcinoma.
Background
The comparative effectiveness of cisplatin-based chemoradiotherapy (CRT) versus cetuximab-based bioradiotherapy (BRT) for locally-advanced head and neck squamous cell carcinoma (LAHNSCC) continues to be explored.
Materials and methods
Outcomes of LAHNSCC patients treated with CRT (125) or BRT (34) at two institutions were compared retrospectively, with attention to overall survival (OS), cancer-specific survival (CSS), locoregional control (LRC), and distant control (DC). Univariate analysis (UVA) using Cox regression was performed to explore the association of intervention with survival and disease control, and multivariate (MVA) Cox regression was then performed to assess the association of intervention with survival.
Results
There were significant baseline differences between the CRT and BRT groups with respect to age, race, performance status, N-classification, tobacco history, and human papillomavirus status. UVA demonstrated inferiority of BRT versus CRT with respect to both OS (hazard ratio [HR] 2.19, 95% confidence interval [95%CI] 1.03–4.63, p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.04) and CSS (HR 3.33, 95%CI 1.42–7.78, p[[ce:hsp sp="0.25"/]]<[[ce:hsp sp="0.25"/]]0.01), but non-significantly different outcomes in LRC (HR 0.99, 95%CI 0.37–2.61, p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.98) and DC (HR 2.01, 95%CI 0.78–5.37, p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.14). On MVA, there was no significant OS difference between interventions (HR 1.19, 95%CI 0.42–3.35, p[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.74); there were too few events for the other outcomes to draw meaningful conclusions with MVA.
Conclusions
In our retrospective analysis, patients undergoing CRT experienced improved OS and CSS over those receiving BRT; however, disease control did not significantly differ. These findings may inform management of LAHNSCC patients.
Keywords: Head and neck cancerChemoradiotherapyCisplatinCetuximabRadiosensitization