open access

Vol 22, No 5 (2017)
Review
Published online: 2017-09-01
Submitted: 2017-01-17
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Biological role of long non-coding RNA in head and neck cancers

Tomasz Kolenda, Kacper Guglas, Marcel Ryś, Marta Bogaczyńska, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna M. Lamperska
DOI: 10.1016/j.rpor.2017.07.001
·
Rep Pract Oncol Radiother 2017;22(5):378-388.

open access

Vol 22, No 5 (2017)
Review
Published online: 2017-09-01
Submitted: 2017-01-17

Abstract

Aim

Head and neck squamous cell carcinoma (HNSCC) are one of the worst prognosis cancers with high mortality of patients. The treatment strategy is primarily based on surgery and radiotherapy but chemotherapy is also used. Every year the knowledge concerning HNSCC biology is updated with new elements such as the recent discovered molecules – long non-coding RNAs. Long non-coding RNAs are involved in regulatory processes in the cells. It has been revealed that the expression levels of lncRNAs are disturbed in tumor cells what results in the acquisition of their specific phenotype. lncRNAs influence cell growth, cell cycle, cell phenotype, migration and invasion ability as well as apoptosis. Development of the lncRNA panel characteristic for HNSCC and validation of specific lncRNA functions are yet to be elucidated. In this work, we collected available data concerning lncRNAs in HNSCC and characterized their biological role. We believe that the tumor examination, in the context of lncRNA expression, may lead to understanding complex biology of the cancer and improve therapeutic methods in the future.

Abstract

Aim

Head and neck squamous cell carcinoma (HNSCC) are one of the worst prognosis cancers with high mortality of patients. The treatment strategy is primarily based on surgery and radiotherapy but chemotherapy is also used. Every year the knowledge concerning HNSCC biology is updated with new elements such as the recent discovered molecules – long non-coding RNAs. Long non-coding RNAs are involved in regulatory processes in the cells. It has been revealed that the expression levels of lncRNAs are disturbed in tumor cells what results in the acquisition of their specific phenotype. lncRNAs influence cell growth, cell cycle, cell phenotype, migration and invasion ability as well as apoptosis. Development of the lncRNA panel characteristic for HNSCC and validation of specific lncRNA functions are yet to be elucidated. In this work, we collected available data concerning lncRNAs in HNSCC and characterized their biological role. We believe that the tumor examination, in the context of lncRNA expression, may lead to understanding complex biology of the cancer and improve therapeutic methods in the future.

Get Citation

Keywords

lncRNA; Non-coding RNA; HNSCC; Biomarker; Cancer biology; Personalized medicine

About this article
Title

Biological role of long non-coding RNA in head and neck cancers

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 22, No 5 (2017)

Pages

378-388

Published online

2017-09-01

DOI

10.1016/j.rpor.2017.07.001

Bibliographic record

Rep Pract Oncol Radiother 2017;22(5):378-388.

Keywords

lncRNA
Non-coding RNA
HNSCC
Biomarker
Cancer biology
Personalized medicine

Authors

Tomasz Kolenda
Kacper Guglas
Marcel Ryś
Marta Bogaczyńska
Anna Teresiak
Renata Bliźniak
Izabela Łasińska
Jacek Mackiewicz
Katarzyna M. Lamperska

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