open access

Vol 22, No 2 (2017)
Special Issue Papers
Published online: 2017-03-01
Submitted: 2015-10-30
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Robotic radiosurgery for the treatment of liver metastases

Rafael García, Iciar Santa-Olalla, Jose Luis Lopez Guerra, Silvia Sanchez, Ignacio Azinovic
DOI: 10.1016/j.rpor.2016.10.002
·
Rep Pract Oncol Radiother 2017;22(2):111-117.

open access

Vol 22, No 2 (2017)
Special Issue Papers
Published online: 2017-03-01
Submitted: 2015-10-30

Abstract

Aim

This study evaluates the toxicity and outcome in patients treated with robotic radiosurgery for liver metastases.

Background

Modern technologies allow the delivery of high doses to the liver metastases while lowering the dose to the neighboring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known yet.

Methods and materials

A total of 9 patients with 17 liver metastases have been treated with robotic stereotactic body radiotherapy SBRT from March 2011 to December 2014. Local response to SBRT was graded by the Response Evaluation Criteria in Solid Tumors criteria to describe change in treated tumor lesion. Adverse events after SBRT were graded on a 1–5 scale according to the National Cancer Institute common terminology criteria for adverse events v4.0.

Results

Patients received either three (78%) or five (22%) fractions. Patients were treated with a mean fraction dose of 14[[ce:hsp sp="0.25"/]]Gy with a range from 9 to 20[[ce:hsp sp="0.25"/]]Gy. The median total radiation dose provided to patients was 45[[ce:hsp sp="0.25"/]]Gy with a range of 45–60[[ce:hsp sp="0.25"/]]Gy. Four out of the 17 (23.5%) treated lesions had a complete response, 9 (53%) partial response and 3 (17.6%) stable disease. With a median follow-up of 15.2 months after SBRT treatment, local control and overall survival rated were 89% and 66%, respectively. No patient experienced grade ≥3 toxicity. The most common toxicity reported was asthenia. Only two patients had nausea and diarrhea, 10 and 14 days after SBRT, respectively.

Conclusions

Robotic radiosurgery is a safe and effective local treatment option for secondary liver tumors. Further prospective studies are ongoing to determine long-term response and survival after robotic-SBRT for liver metastases.

Abstract

Aim

This study evaluates the toxicity and outcome in patients treated with robotic radiosurgery for liver metastases.

Background

Modern technologies allow the delivery of high doses to the liver metastases while lowering the dose to the neighboring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known yet.

Methods and materials

A total of 9 patients with 17 liver metastases have been treated with robotic stereotactic body radiotherapy SBRT from March 2011 to December 2014. Local response to SBRT was graded by the Response Evaluation Criteria in Solid Tumors criteria to describe change in treated tumor lesion. Adverse events after SBRT were graded on a 1–5 scale according to the National Cancer Institute common terminology criteria for adverse events v4.0.

Results

Patients received either three (78%) or five (22%) fractions. Patients were treated with a mean fraction dose of 14[[ce:hsp sp="0.25"/]]Gy with a range from 9 to 20[[ce:hsp sp="0.25"/]]Gy. The median total radiation dose provided to patients was 45[[ce:hsp sp="0.25"/]]Gy with a range of 45–60[[ce:hsp sp="0.25"/]]Gy. Four out of the 17 (23.5%) treated lesions had a complete response, 9 (53%) partial response and 3 (17.6%) stable disease. With a median follow-up of 15.2 months after SBRT treatment, local control and overall survival rated were 89% and 66%, respectively. No patient experienced grade ≥3 toxicity. The most common toxicity reported was asthenia. Only two patients had nausea and diarrhea, 10 and 14 days after SBRT, respectively.

Conclusions

Robotic radiosurgery is a safe and effective local treatment option for secondary liver tumors. Further prospective studies are ongoing to determine long-term response and survival after robotic-SBRT for liver metastases.

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Keywords

Robotic radiosurgery; Liver metastases; Radiosurgery

About this article
Title

Robotic radiosurgery for the treatment of liver metastases

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 22, No 2 (2017)

Pages

111-117

Published online

2017-03-01

DOI

10.1016/j.rpor.2016.10.002

Bibliographic record

Rep Pract Oncol Radiother 2017;22(2):111-117.

Keywords

Robotic radiosurgery
Liver metastases
Radiosurgery

Authors

Rafael García
Iciar Santa-Olalla
Jose Luis Lopez Guerra
Silvia Sanchez
Ignacio Azinovic

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