open access

Vol 22, No 2 (2017)
Special Issue Papers
Published online: 2017-03-01
Submitted: 2016-01-10
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Dose to organ at risk and dose prescription in liver SBRT

Rives Michel, Izar Françoise, Parent Laure, Modesto Anouchka, Portier Guillaume, Kirzin Sylvain
DOI: 10.1016/j.rpor.2017.03.001
·
Rep Pract Oncol Radiother 2017;22(2):96-102.

open access

Vol 22, No 2 (2017)
Special Issue Papers
Published online: 2017-03-01
Submitted: 2016-01-10

Abstract

Stereotactic body radiation therapy (SBRT) is delivered in a curative intent to many primary and secondary tumors.

Concerning liver metastasis, SBRT can be safely delivered using one to five fractions. An excellent local control is obtained with doses from 20 to 60[[ce:hsp sp="0.25"/]]Gy. For primary hepatic tumors, results are also good, but the risk of hepatic toxicity related to liver pre-existent pathology must be taken into account. Radiation induced liver disease (RILD) is not frequent in its classical presentation, but modifications of liver enzymes are often observed. Other toxicities of SBRT on the duodenum, small bowel and biliary tract are also described. With respect to contraindications and dose limitations on surrounding structures, SBRT is well tolerated and takes place among curative treatment of liver tumors, as surgery, radiofrequency and embolization.

Abstract

Stereotactic body radiation therapy (SBRT) is delivered in a curative intent to many primary and secondary tumors.

Concerning liver metastasis, SBRT can be safely delivered using one to five fractions. An excellent local control is obtained with doses from 20 to 60[[ce:hsp sp="0.25"/]]Gy. For primary hepatic tumors, results are also good, but the risk of hepatic toxicity related to liver pre-existent pathology must be taken into account. Radiation induced liver disease (RILD) is not frequent in its classical presentation, but modifications of liver enzymes are often observed. Other toxicities of SBRT on the duodenum, small bowel and biliary tract are also described. With respect to contraindications and dose limitations on surrounding structures, SBRT is well tolerated and takes place among curative treatment of liver tumors, as surgery, radiofrequency and embolization.

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Keywords

Liver; Stereotactic; Radiotherapy; Toxicity; Metastasis; Hepatocellular

About this article
Title

Dose to organ at risk and dose prescription in liver SBRT

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 22, No 2 (2017)

Pages

96-102

Published online

2017-03-01

DOI

10.1016/j.rpor.2017.03.001

Bibliographic record

Rep Pract Oncol Radiother 2017;22(2):96-102.

Keywords

Liver
Stereotactic
Radiotherapy
Toxicity
Metastasis
Hepatocellular

Authors

Rives Michel
Izar Françoise
Parent Laure
Modesto Anouchka
Portier Guillaume
Kirzin Sylvain

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