open access

Vol 21, No 6 (2016)
Original research articles
Published online: 2016-11-01
Submitted: 2016-04-06
Get Citation

Comprehensive assessment of Somnolence Syndrome in patients undergoing radiation to the brain

Ritika R. Harjani, Janaki Manur Gururajachar, Umamaheswari Krishnaswamy
DOI: 10.1016/j.rpor.2016.08.003
·
Rep Pract Oncol Radiother 2016;21(6):560-566.

open access

Vol 21, No 6 (2016)
Original research articles
Published online: 2016-11-01
Submitted: 2016-04-06

Abstract

Aim

The aim of this prospective study was to assess Somnolence Syndrome (SS) in patients undergoing radiation to the brain.

Background

SS is one of the sequelae of radiation to the brain, which is observed within three months of radiation. This is a self-limiting condition and a failure to diagnose leads to unnecessary investigations. This study was undertaken to objectively and subjectively analyze the occurrence, clinical presentation and severity of SS.

Materials and methods

Thirty-three patients receiving radiation to the brain were included in the study. Visual Analog Scale (VAS) was used for subjective assessment and the Littman Somnolence Syndrome (LSS) scale was used for objective assessment of SS. Sleep Latency Test (SLT) was used to quantify SS.

Results

VAS scores showed an initial fall until week 3, followed by a plateau and a sudden increase after week 10. LSS scale at week 11 and 12 showed that 13 patients (43.3%) had grade 2, 5 (16.7%) had grade 3; and 2 (6.7%) had grade 4 SS. SLT revealed a shift of predominant sleep pattern from NREM 1 to NREM 2 at 6 weeks after radiation with a p value of 0.0412.

Conclusions

An insight into SS, its features, frequency of occurrence and self limiting nature can prevent anxiety and unwarranted investigations in the immediate post radiation period.

Abstract

Aim

The aim of this prospective study was to assess Somnolence Syndrome (SS) in patients undergoing radiation to the brain.

Background

SS is one of the sequelae of radiation to the brain, which is observed within three months of radiation. This is a self-limiting condition and a failure to diagnose leads to unnecessary investigations. This study was undertaken to objectively and subjectively analyze the occurrence, clinical presentation and severity of SS.

Materials and methods

Thirty-three patients receiving radiation to the brain were included in the study. Visual Analog Scale (VAS) was used for subjective assessment and the Littman Somnolence Syndrome (LSS) scale was used for objective assessment of SS. Sleep Latency Test (SLT) was used to quantify SS.

Results

VAS scores showed an initial fall until week 3, followed by a plateau and a sudden increase after week 10. LSS scale at week 11 and 12 showed that 13 patients (43.3%) had grade 2, 5 (16.7%) had grade 3; and 2 (6.7%) had grade 4 SS. SLT revealed a shift of predominant sleep pattern from NREM 1 to NREM 2 at 6 weeks after radiation with a p value of 0.0412.

Conclusions

An insight into SS, its features, frequency of occurrence and self limiting nature can prevent anxiety and unwarranted investigations in the immediate post radiation period.

Get Citation

Keywords

Somnolence Syndrome; Brain irradiation; VAS; Littman score; Sleep Latency Test

About this article
Title

Comprehensive assessment of Somnolence Syndrome in patients undergoing radiation to the brain

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 6 (2016)

Pages

560-566

Published online

2016-11-01

DOI

10.1016/j.rpor.2016.08.003

Bibliographic record

Rep Pract Oncol Radiother 2016;21(6):560-566.

Keywords

Somnolence Syndrome
Brain irradiation
VAS
Littman score
Sleep Latency Test

Authors

Ritika R. Harjani
Janaki Manur Gururajachar
Umamaheswari Krishnaswamy

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