open access

Vol 21, No 5 (2016)
Original research articles
Published online: 2016-09-01
Submitted: 2016-02-15
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Outcome of radiotherapy for pituitary adenomas

Patricia Sebastian, Rajesh Balakrishnan, Bijesh Yadav, Subhashini John
DOI: 10.1016/j.rpor.2016.06.002
·
Rep Pract Oncol Radiother 2016;21(5):466-472.

open access

Vol 21, No 5 (2016)
Original research articles
Published online: 2016-09-01
Submitted: 2016-02-15

Abstract

Aim

The aim of this study was to analyze the outcome and toxicities and its correlation to patient related and treatment related factors.

Background

Pituitary adenomas are treated by radiation therapy (RT) as one of the modalities along with surgery and medical therapy. RT to pituitary adenomas is a challenge due to adjacent dose limiting structures such as optic apparatus and hypothalamus.

Materials and methods

Between January 2004 and December 2010, 94 patients treated for pituitary adenoma with RT who had hospital records of a minimum follow-up of 1 year were included in the analysis. Tests of correlation were done with regards to treatment factors.

Results

Male preponderance was noted in our patient population. Nonfunctioning and functioning tumors were equal in number in this series. Hypopituitarism was associated in 58.5% of patients prior to RT. Radiological tumor progression was seen in one patient (1/94) who had a nonfunctioning tumor. Among functioning tumors, biochemical remission was seen in 93.6% of patients at a median follow-up of 6 years.

Conclusions

Visual complication was seen in 5.3% of patients and worsening or new onset hypopituitarism was seen in 6.4%. Conventional 3-field technique was associated with significantly more visual complication compared to Stereotactic Radiation Therapy (SRT) technique. Doses ≤50.4[[ce:hsp sp="0.25"/]]Gy showed a trend of reduced rate of visual and endocrine complications with no compromise in efficacy.

Abstract

Aim

The aim of this study was to analyze the outcome and toxicities and its correlation to patient related and treatment related factors.

Background

Pituitary adenomas are treated by radiation therapy (RT) as one of the modalities along with surgery and medical therapy. RT to pituitary adenomas is a challenge due to adjacent dose limiting structures such as optic apparatus and hypothalamus.

Materials and methods

Between January 2004 and December 2010, 94 patients treated for pituitary adenoma with RT who had hospital records of a minimum follow-up of 1 year were included in the analysis. Tests of correlation were done with regards to treatment factors.

Results

Male preponderance was noted in our patient population. Nonfunctioning and functioning tumors were equal in number in this series. Hypopituitarism was associated in 58.5% of patients prior to RT. Radiological tumor progression was seen in one patient (1/94) who had a nonfunctioning tumor. Among functioning tumors, biochemical remission was seen in 93.6% of patients at a median follow-up of 6 years.

Conclusions

Visual complication was seen in 5.3% of patients and worsening or new onset hypopituitarism was seen in 6.4%. Conventional 3-field technique was associated with significantly more visual complication compared to Stereotactic Radiation Therapy (SRT) technique. Doses ≤50.4[[ce:hsp sp="0.25"/]]Gy showed a trend of reduced rate of visual and endocrine complications with no compromise in efficacy.

Get Citation

Keywords

Radiotherapy; Pituitary; Complications; Visual; Hypopituitarism; RT; CT; MRI; GH; ACTH; FSH; MV; SRT; 3DCRT; GTC; SPSS; CR; SD; PR; Gy; cGy; SRS; FSRT

About this article
Title

Outcome of radiotherapy for pituitary adenomas

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 5 (2016)

Pages

466-472

Published online

2016-09-01

DOI

10.1016/j.rpor.2016.06.002

Bibliographic record

Rep Pract Oncol Radiother 2016;21(5):466-472.

Keywords

Radiotherapy
Pituitary
Complications
Visual
Hypopituitarism
RT
CT
MRI
GH
ACTH
FSH
MV
SRT
3DCRT
GTC
SPSS
CR
SD
PR
Gy
cGy
SRS
FSRT

Authors

Patricia Sebastian
Rajesh Balakrishnan
Bijesh Yadav
Subhashini John

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