open access

Vol 21, No 4 (2016)
Special Issue Papers
Published online: 2016-07-01
Submitted: 2015-07-29
Get Citation

Tumour seeding in the surgical pathway after resection of skull base chordoma

Marco Krengli, Arturo Poletti, Eleonora Ferrara, Piero Fossati
DOI: 10.1016/j.rpor.2016.02.005
·
Rep Pract Oncol Radiother 2016;21(4):407-411.

open access

Vol 21, No 4 (2016)
Special Issue Papers
Published online: 2016-07-01
Submitted: 2015-07-29

Abstract

Aim

The aim of this study is to review the clinical series in which tumour seeding was reported after skull base surgery for chordomas.

Background

The occurrence of implantation of cancer cells during surgical procedures for the removal of chordoma is a rare event described by a number of authors in a few patient series and case reports.

Materials and methods

Literature search was performed by PubMed and Scopus by using the words “surgical tumour seeding, tumour implantation, surgical pathway recurrence, skull base chordoma, and clivus chordoma”.

Results

Six retrospective series and 7 case reports were included in the analysis. In total, 34 patients are described with pathway recurrence, 30 at a single site and 4 at multiple sites.

In the 5 largest chordoma series, the rate of occurrence of surgical seeding ranged from 1.3% to 7.3% (3.9%). In the 34 patients diagnosed with tumour seeding, the most frequent surgical approach was trans-nasal/trans-sphenoidal, that was used in 12 cases. The median time from primary treatment to surgical pathway tumour seeding ranged from 7 to 78 months. Data of the treatment of seeding are available in 26/34 patients. All of them underwent a new surgery, 6 received additional external beam radiotherapy, and 2 intraoperative radiotherapy.

Conclusions

The risk of surgical seeding should be taken into consideration when deciding on the surgical approach and the planning treatment volume for postoperative radiation therapy. The surgical pathway should be included in follow-up studies to diagnose this peculiar type of treatment failure possibly at an early phase.

Abstract

Aim

The aim of this study is to review the clinical series in which tumour seeding was reported after skull base surgery for chordomas.

Background

The occurrence of implantation of cancer cells during surgical procedures for the removal of chordoma is a rare event described by a number of authors in a few patient series and case reports.

Materials and methods

Literature search was performed by PubMed and Scopus by using the words “surgical tumour seeding, tumour implantation, surgical pathway recurrence, skull base chordoma, and clivus chordoma”.

Results

Six retrospective series and 7 case reports were included in the analysis. In total, 34 patients are described with pathway recurrence, 30 at a single site and 4 at multiple sites.

In the 5 largest chordoma series, the rate of occurrence of surgical seeding ranged from 1.3% to 7.3% (3.9%). In the 34 patients diagnosed with tumour seeding, the most frequent surgical approach was trans-nasal/trans-sphenoidal, that was used in 12 cases. The median time from primary treatment to surgical pathway tumour seeding ranged from 7 to 78 months. Data of the treatment of seeding are available in 26/34 patients. All of them underwent a new surgery, 6 received additional external beam radiotherapy, and 2 intraoperative radiotherapy.

Conclusions

The risk of surgical seeding should be taken into consideration when deciding on the surgical approach and the planning treatment volume for postoperative radiation therapy. The surgical pathway should be included in follow-up studies to diagnose this peculiar type of treatment failure possibly at an early phase.

Get Citation

Keywords

Surgery; Tumour seeding; Surgical pathway recurrence; Skull base chordoma

About this article
Title

Tumour seeding in the surgical pathway after resection of skull base chordoma

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 4 (2016)

Pages

407-411

Published online

2016-07-01

DOI

10.1016/j.rpor.2016.02.005

Bibliographic record

Rep Pract Oncol Radiother 2016;21(4):407-411.

Keywords

Surgery
Tumour seeding
Surgical pathway recurrence
Skull base chordoma

Authors

Marco Krengli
Arturo Poletti
Eleonora Ferrara
Piero Fossati

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl