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Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence
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Abstract
Aim
Prognostic factors, rational management, and the ongoing investigations regarding temporal bone squamous cell carcinoma (TBSCC) have been critically reviewed.
Background
TBSCC is an uncommon, aggressive malignancy. Although some progress has been made in treating this aggressive tumor, the prognosis in advanced cases remains poor.
Materials and methods
A systematic search of the literature for articles published between 2009 and October 2014 was performed using the PubMed ([[ce:inter-ref id="intr0005" xlink:href="http://www.pubmed.gov/"]]http://www.pubmed.gov) electronic database.
Results
Given the particular anatomical site of TBSCC, its prognosis is significantly influenced by any direct involvement of nearby structures. The extent of the primary tumor is generally considered one of the most important prognostic factors and it is frequently related to prognosis even more strongly than N stage. For TBSCC, biomarker investigations in surgical specimens are only just beginning to appear in the oncological literature.
Conclusion
Given the particular features of TBSCC, the sub-specialty of otologic oncology seems to be emerging as a defined area of practice involving multidisciplinary team comprising oto-neurosurgeons, head and neck surgeons, plastic surgeons, oncologists, radiotherapists, dedicated radiologists, and pathologists.
Abstract
Aim
Prognostic factors, rational management, and the ongoing investigations regarding temporal bone squamous cell carcinoma (TBSCC) have been critically reviewed.
Background
TBSCC is an uncommon, aggressive malignancy. Although some progress has been made in treating this aggressive tumor, the prognosis in advanced cases remains poor.
Materials and methods
A systematic search of the literature for articles published between 2009 and October 2014 was performed using the PubMed ([[ce:inter-ref id="intr0005" xlink:href="http://www.pubmed.gov/"]]http://www.pubmed.gov) electronic database.
Results
Given the particular anatomical site of TBSCC, its prognosis is significantly influenced by any direct involvement of nearby structures. The extent of the primary tumor is generally considered one of the most important prognostic factors and it is frequently related to prognosis even more strongly than N stage. For TBSCC, biomarker investigations in surgical specimens are only just beginning to appear in the oncological literature.
Conclusion
Given the particular features of TBSCC, the sub-specialty of otologic oncology seems to be emerging as a defined area of practice involving multidisciplinary team comprising oto-neurosurgeons, head and neck surgeons, plastic surgeons, oncologists, radiotherapists, dedicated radiologists, and pathologists.
Keywords
Temporal bone; Squamous cell carcinoma; Prognosis
About this articleTitle
Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
386-390
Published online
2016-07-01
DOI
10.1016/j.rpor.2015.07.004
Bibliographic record
Rep Pract Oncol Radiother 2016;21(4):386-390.
Keywords
Temporal bone
Squamous cell carcinoma
Prognosis
Authors
Elisabetta Zanoletti
Gino Marioni
Sebastiano Franchella
Sara Munari
Roberto Pareschi
Antonio Mazzoni
Alessandro Martini