open access

Vol 21, No 3 (2016)
Original research articles
Published online: 2016-05-01
Submitted: 2016-02-16
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Risk factors for seroma evacuation in breast cancer patients treated with intraoperative radiotherapy

Michał Falco, Bartłomiej Masojć, Magdalena Rolla, Agnieszka Czekała, Jolanta Pietruszewska, Agnieszka Rubik-Leszczyńska, Mirosław Lewocki, Magdalena Łukowiak, Andrzej Kram
DOI: 10.1016/j.rpor.2016.03.003
·
Rep Pract Oncol Radiother 2016;21(3):225-231.

open access

Vol 21, No 3 (2016)
Original research articles
Published online: 2016-05-01
Submitted: 2016-02-16

Abstract

Background

Novel techniques in oncology provide new treatment opportunities but also introduce different patterns of side effects. Intraoperative radiotherapy (IORT) allows a shortened overall treatment time for early breast cancer either combined with whole breast radiotherapy (WBRT), or alone. Although the early side effects of IORT are well known, data on clinically important late side effects, which require medical intervention, are scarce.

Aim

In this study, we analyze risk factors for seroma evacuation more than 6 months after IORT.

Materials and methods

We evaluated 120 patients with a mean follow-up of 27.8 months (range: 7–52 months). Fifty-one patients received IORT only and 69 were additionally treated with WBRT.

Results

Seroma evacuation was performed 6–38 months after IORT. Two (3.9%) events were observed in the IORT group and 14 (20%) in the IORT[[ce:hsp sp="0.25"/]]+[[ce:hsp sp="0.25"/]]WBRT group. Univariate (Kaplan–Meier) analysis showed that addition of WBRT to IORT increased the risk of seroma evacuation [hazard ratio[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]5.5, 95% confidence interval: 2.0–14.7, P[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.011]. In a multivariate analysis (Cox proportional hazards regression), WBRT and axillary lymph node dissection were significant risk factors for seroma evacuation (model P value[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.0025).

Conclusions

WBRT applied after IORT is associated with increased risk of seroma evacuation, which might be considered as a late side effect.

Abstract

Background

Novel techniques in oncology provide new treatment opportunities but also introduce different patterns of side effects. Intraoperative radiotherapy (IORT) allows a shortened overall treatment time for early breast cancer either combined with whole breast radiotherapy (WBRT), or alone. Although the early side effects of IORT are well known, data on clinically important late side effects, which require medical intervention, are scarce.

Aim

In this study, we analyze risk factors for seroma evacuation more than 6 months after IORT.

Materials and methods

We evaluated 120 patients with a mean follow-up of 27.8 months (range: 7–52 months). Fifty-one patients received IORT only and 69 were additionally treated with WBRT.

Results

Seroma evacuation was performed 6–38 months after IORT. Two (3.9%) events were observed in the IORT group and 14 (20%) in the IORT[[ce:hsp sp="0.25"/]]+[[ce:hsp sp="0.25"/]]WBRT group. Univariate (Kaplan–Meier) analysis showed that addition of WBRT to IORT increased the risk of seroma evacuation [hazard ratio[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]5.5, 95% confidence interval: 2.0–14.7, P[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.011]. In a multivariate analysis (Cox proportional hazards regression), WBRT and axillary lymph node dissection were significant risk factors for seroma evacuation (model P value[[ce:hsp sp="0.25"/]]=[[ce:hsp sp="0.25"/]]0.0025).

Conclusions

WBRT applied after IORT is associated with increased risk of seroma evacuation, which might be considered as a late side effect.

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Keywords

Breast cancer; Intraoperative radiotherapy; Side effects; Seroma; Accelerated partial breast irradiation

About this article
Title

Risk factors for seroma evacuation in breast cancer patients treated with intraoperative radiotherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 3 (2016)

Pages

225-231

Published online

2016-05-01

DOI

10.1016/j.rpor.2016.03.003

Bibliographic record

Rep Pract Oncol Radiother 2016;21(3):225-231.

Keywords

Breast cancer
Intraoperative radiotherapy
Side effects
Seroma
Accelerated partial breast irradiation

Authors

Michał Falco
Bartłomiej Masojć
Magdalena Rolla
Agnieszka Czekała
Jolanta Pietruszewska
Agnieszka Rubik-Leszczyńska
Mirosław Lewocki
Magdalena Łukowiak
Andrzej Kram

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