open access

Vol 21, No 3 (2016)
Review
Published online: 2016-05-01
Submitted: 2015-10-18
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Radiotherapy for Graves’ disease. The possible role of low-dose radiotherapy

Meritxell Arenas, Sebastià Sabater, Pedro Lara Jiménez, Àngels Rovirosa, Albert Biete, Victoria Linares, Montse Belles, Julià Panés
DOI: 10.1016/j.rpor.2016.02.001
·
Rep Pract Oncol Radiother 2016;21(3):213-218.

open access

Vol 21, No 3 (2016)
Review
Published online: 2016-05-01
Submitted: 2015-10-18

Abstract

Immunomodulatory effects of low-dose radiotherapy (LD-RT) have been used for the treatment of several benign diseases, including arthrodegenerative and inflammatory pathologies. Graves’ disease is an autoimmune disease and radiotherapy (RT) is a therapeutic option for ocular complications. The dose recommended in the clinical practice is 20[[ce:hsp sp="0.25"/]]Gy (2[[ce:hsp sp="0.25"/]]Gy/day). We hypothesized that lower doses (<10[[ce:hsp sp="0.25"/]]Gy total dose, <1[[ce:hsp sp="0.25"/]]Gy/day) could results in higher efficacy if we achieved anti-inflammatory and immunomodulatory effects of LD-RT.

We review current evidence on the effects of RT in the treatment of Graves’ disease and the possible use of LD-RT treatment strategy.

Abstract

Immunomodulatory effects of low-dose radiotherapy (LD-RT) have been used for the treatment of several benign diseases, including arthrodegenerative and inflammatory pathologies. Graves’ disease is an autoimmune disease and radiotherapy (RT) is a therapeutic option for ocular complications. The dose recommended in the clinical practice is 20[[ce:hsp sp="0.25"/]]Gy (2[[ce:hsp sp="0.25"/]]Gy/day). We hypothesized that lower doses (<10[[ce:hsp sp="0.25"/]]Gy total dose, <1[[ce:hsp sp="0.25"/]]Gy/day) could results in higher efficacy if we achieved anti-inflammatory and immunomodulatory effects of LD-RT.

We review current evidence on the effects of RT in the treatment of Graves’ disease and the possible use of LD-RT treatment strategy.

Get Citation

Keywords

Low-dose radiotherapy; Graves’ ophthalmopathy; Radiotherapy for benign disease

About this article
Title

Radiotherapy for Graves’ disease. The possible role of low-dose radiotherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 3 (2016)

Pages

213-218

Published online

2016-05-01

DOI

10.1016/j.rpor.2016.02.001

Bibliographic record

Rep Pract Oncol Radiother 2016;21(3):213-218.

Keywords

Low-dose radiotherapy
Graves’ ophthalmopathy
Radiotherapy for benign disease

Authors

Meritxell Arenas
Sebastià Sabater
Pedro Lara Jiménez
Àngels Rovirosa
Albert Biete
Victoria Linares
Montse Belles
Julià Panés

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