open access

Vol 21, No 2 (2016)
Special Issue Papers
Published online: 2016-03-01
Submitted: 2014-03-18
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An improved neutron autoradiography set-up for B concentration measurements in biological samples

Ian Postuma, Silva Bortolussi, Nicoletta Protti, Francesca Ballarini, Piero Bruschi, Laura Ciani, Sandra Ristori, Luigi Panza, Cinzia Ferrari, Laura Cansolino, Saverio Altieri
DOI: 10.1016/j.rpor.2015.10.006
·
Rep Pract Oncol Radiother 2016;21(2):123-128.

open access

Vol 21, No 2 (2016)
Special Issue Papers
Published online: 2016-03-01
Submitted: 2014-03-18

Abstract

Aim

Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA).

Background

Therefore, a 10B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations.

Materials and methods

This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions.

Results

Calibration curves for both liquid and tissue samples were obtained.

Conclusions

The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.

Abstract

Aim

Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA).

Background

Therefore, a 10B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations.

Materials and methods

This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions.

Results

Calibration curves for both liquid and tissue samples were obtained.

Conclusions

The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.

Get Citation

Keywords

Boron Neutron Capture Therapy; Boron concentration; Neutron autoradiography; CR-39

About this article
Title

An improved neutron autoradiography set-up for B concentration measurements in biological samples

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 2 (2016)

Pages

123-128

Published online

2016-03-01

DOI

10.1016/j.rpor.2015.10.006

Bibliographic record

Rep Pract Oncol Radiother 2016;21(2):123-128.

Keywords

Boron Neutron Capture Therapy
Boron concentration
Neutron autoradiography
CR-39

Authors

Ian Postuma
Silva Bortolussi
Nicoletta Protti
Francesca Ballarini
Piero Bruschi
Laura Ciani
Sandra Ristori
Luigi Panza
Cinzia Ferrari
Laura Cansolino
Saverio Altieri

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