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An improved neutron autoradiography set-up for B concentration measurements in biological samples
open access
Abstract
Aim
Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA).
Background
Therefore, a 10B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations.
Materials and methods
This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions.
Results
Calibration curves for both liquid and tissue samples were obtained.
Conclusions
The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.
Abstract
Aim
Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA).
Background
Therefore, a 10B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations.
Materials and methods
This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions.
Results
Calibration curves for both liquid and tissue samples were obtained.
Conclusions
The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.
Keywords
Boron Neutron Capture Therapy; Boron concentration; Neutron autoradiography; CR-39
About this articleTitle
An improved neutron autoradiography set-up for B concentration measurements in biological samples
Journal
Reports of Practical Oncology and Radiotherapy
Issue
Pages
123-128
Published online
2016-03-01
DOI
10.1016/j.rpor.2015.10.006
Bibliographic record
Rep Pract Oncol Radiother 2016;21(2):123-128.
Keywords
Boron Neutron Capture Therapy
Boron concentration
Neutron autoradiography
CR-39
Authors
Ian Postuma
Silva Bortolussi
Nicoletta Protti
Francesca Ballarini
Piero Bruschi
Laura Ciani
Sandra Ristori
Luigi Panza
Cinzia Ferrari
Laura Cansolino
Saverio Altieri