open access

Vol 21, No 1 (2016)
Original research articles
Published online: 2016-01-01
Submitted: 2014-08-02
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Tissue composition effect on dose distribution in neutron brachytherapy/neutron capture therapy

Mohsen Khosroabadi, Bagher Farhood, Mahdi Ghorbani, Nima Hamzian, Homa Rezaei Moghaddam, David Davenport
DOI: 10.1016/j.rpor.2015.05.001
·
Rep Pract Oncol Radiother 2016;21(1):8-16.

open access

Vol 21, No 1 (2016)
Original research articles
Published online: 2016-01-01
Submitted: 2014-08-02

Abstract

Aim

The aim of this study is to assess the effect of the compositions of various soft tissues and tissue-equivalent materials on dose distribution in neutron brachytherapy/neutron capture therapy.

Background

Neutron brachytherapy and neutron capture therapy are two common radiotherapy modalities.

Materials and methods

Dose distributions were calculated around a low dose rate 252Cf source located in a spherical phantom with radius of 20.0[[ce:hsp sp="0.25"/]]cm using the MCNPX code for seven soft tissues and three tissue-equivalent materials. Relative total dose rate, relative neutron dose rate, total dose rate, and neutron dose rate were calculated for each material. These values were determined at various radial distances ranging from 0.3 to 15.0[[ce:hsp sp="0.25"/]]cm from the source.

Results

Among the soft tissues and tissue-equivalent materials studied, adipose tissue and plexiglass demonstrated the greatest differences for total dose rate compared to 9-component soft tissue. The difference in dose rate with respect to 9-component soft tissue varied with compositions of the materials and the radial distance from the source. Furthermore, the total dose rate in water was different from that in 9-component soft tissue.

Conclusion

Taking the same composition for various soft tissues and tissue-equivalent media can lead to error in treatment planning in neutron brachytherapy/neutron capture therapy. Since the International Commission on Radiation Units and Measurements (ICRU) recommends that the total dosimetric uncertainty in dose delivery in radiotherapy should be within ±5%, the compositions of various soft tissues and tissue-equivalent materials should be considered in dose calculation and treatment planning in neutron brachytherapy/neutron capture therapy.

Abstract

Aim

The aim of this study is to assess the effect of the compositions of various soft tissues and tissue-equivalent materials on dose distribution in neutron brachytherapy/neutron capture therapy.

Background

Neutron brachytherapy and neutron capture therapy are two common radiotherapy modalities.

Materials and methods

Dose distributions were calculated around a low dose rate 252Cf source located in a spherical phantom with radius of 20.0[[ce:hsp sp="0.25"/]]cm using the MCNPX code for seven soft tissues and three tissue-equivalent materials. Relative total dose rate, relative neutron dose rate, total dose rate, and neutron dose rate were calculated for each material. These values were determined at various radial distances ranging from 0.3 to 15.0[[ce:hsp sp="0.25"/]]cm from the source.

Results

Among the soft tissues and tissue-equivalent materials studied, adipose tissue and plexiglass demonstrated the greatest differences for total dose rate compared to 9-component soft tissue. The difference in dose rate with respect to 9-component soft tissue varied with compositions of the materials and the radial distance from the source. Furthermore, the total dose rate in water was different from that in 9-component soft tissue.

Conclusion

Taking the same composition for various soft tissues and tissue-equivalent media can lead to error in treatment planning in neutron brachytherapy/neutron capture therapy. Since the International Commission on Radiation Units and Measurements (ICRU) recommends that the total dosimetric uncertainty in dose delivery in radiotherapy should be within ±5%, the compositions of various soft tissues and tissue-equivalent materials should be considered in dose calculation and treatment planning in neutron brachytherapy/neutron capture therapy.

Get Citation

Keywords

Neutron brachytherapy; Neutron capture therapy; Tissue composition; Dose rate; [[ce:sup loc=" pre" ]]252Cf

About this article
Title

Tissue composition effect on dose distribution in neutron brachytherapy/neutron capture therapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 21, No 1 (2016)

Pages

8-16

Published online

2016-01-01

DOI

10.1016/j.rpor.2015.05.001

Bibliographic record

Rep Pract Oncol Radiother 2016;21(1):8-16.

Keywords

Neutron brachytherapy
Neutron capture therapy
Tissue composition
Dose rate
[[ce:sup loc="pre"]]252Cf

Authors

Mohsen Khosroabadi
Bagher Farhood
Mahdi Ghorbani
Nima Hamzian
Homa Rezaei Moghaddam
David Davenport

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