open access

Vol 20, No 4 (2015)
Original research articles
Published online: 2015-07-01
Submitted: 2014-08-21
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Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program

Michela Buglione, Paolo Ghirardelli, Luca Triggiani, Sara Pedretti, Nadia Pasinetti, Berardino De Bari, Sandro Tonoli, Paolo Borghetti, Luigi Spiazzi, Stefano Maria Magrini
DOI: 10.1016/j.rpor.2015.03.003
·
Rep Pract Oncol Radiother 2015;20(4):284-291.

open access

Vol 20, No 4 (2015)
Original research articles
Published online: 2015-07-01
Submitted: 2014-08-21

Abstract

Aim

We retrospectively analyzed our Institution experience with these patients. The endpoints of the analysis were overall survival (OS), disease-free survival (DFS), local control (LC), metastasis free survival (MFS); results were compared with the literature.

Background

Medulloblastoma in adult patients is a very rare disease; the 5 and 10-year overall survival rates range between 33–78% and 27–56%, respectively. The collection of more clinical data is strongly needed.

Materials and methods

From September 1975 to October 2006, we treated 16 adult patients (9 males and 7 females) with a histological diagnosis of medulloblastoma. Acute and late toxicities were scored according to RTOG toxicity scale. Karnofski performance status (KPS) and neurological performance status (NPS) pre- and post-RT were reported.

Median age was 27 years (range 18–53 years). All the patients received cranio-spinal irradiation, two patients were also given chemotherapy. Median follow-up period was 121.5 months.

Results

In January 2014, 10/16 patients were alive without evidence of disease, 6/16 died with progressive disease (1 local and spinal, 3 spinal and 2 extraneural). Ten-year LC, OS, DFS, MFS were, respectively, 84%, 67%, 60% and 59%. Univariate analysis shows that gross total resection is associated with better survival.

No acute or late G3–G4 toxicity was observed.

Conclusions

This experience and the analysis of the literature confirm the efficacy of postoperative RT but also the need of large datasets to better define prognostic factors and the possible role of the association of chemotherapy.

Abstract

Aim

We retrospectively analyzed our Institution experience with these patients. The endpoints of the analysis were overall survival (OS), disease-free survival (DFS), local control (LC), metastasis free survival (MFS); results were compared with the literature.

Background

Medulloblastoma in adult patients is a very rare disease; the 5 and 10-year overall survival rates range between 33–78% and 27–56%, respectively. The collection of more clinical data is strongly needed.

Materials and methods

From September 1975 to October 2006, we treated 16 adult patients (9 males and 7 females) with a histological diagnosis of medulloblastoma. Acute and late toxicities were scored according to RTOG toxicity scale. Karnofski performance status (KPS) and neurological performance status (NPS) pre- and post-RT were reported.

Median age was 27 years (range 18–53 years). All the patients received cranio-spinal irradiation, two patients were also given chemotherapy. Median follow-up period was 121.5 months.

Results

In January 2014, 10/16 patients were alive without evidence of disease, 6/16 died with progressive disease (1 local and spinal, 3 spinal and 2 extraneural). Ten-year LC, OS, DFS, MFS were, respectively, 84%, 67%, 60% and 59%. Univariate analysis shows that gross total resection is associated with better survival.

No acute or late G3–G4 toxicity was observed.

Conclusions

This experience and the analysis of the literature confirm the efficacy of postoperative RT but also the need of large datasets to better define prognostic factors and the possible role of the association of chemotherapy.

Get Citation

Keywords

Adult medulloblastoma; Cranio-spinal irradiation; Chemotherapy

About this article
Title

Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 20, No 4 (2015)

Pages

284-291

Published online

2015-07-01

DOI

10.1016/j.rpor.2015.03.003

Bibliographic record

Rep Pract Oncol Radiother 2015;20(4):284-291.

Keywords

Adult medulloblastoma
Cranio-spinal irradiation
Chemotherapy

Authors

Michela Buglione
Paolo Ghirardelli
Luca Triggiani
Sara Pedretti
Nadia Pasinetti
Berardino De Bari
Sandro Tonoli
Paolo Borghetti
Luigi Spiazzi
Stefano Maria Magrini

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