open access

Vol 20, No 2 (2015)
Original research articles
Published online: 2015-03-01
Submitted: 2013-07-01
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Integral dose: Comparison between four techniques for prostate radiotherapy

Krzysztof Ślosarek, Wojciech Osewski, Aleksandra Grządziel, Michał Radwan, Łukasz Dolla, Marta Szlag, Małgorzata Stąpór-Fudzińska
DOI: 10.1016/j.rpor.2014.10.010
·
Rep Pract Oncol Radiother 2015;20(2):99-103.

open access

Vol 20, No 2 (2015)
Original research articles
Published online: 2015-03-01
Submitted: 2013-07-01

Abstract

Aim

Comparisons of integral dose delivered to the treatment planning volume and to the whole patient body during stereotactic, helical and intensity modulated radiotherapy of prostate.

Background

Multifield techniques produce large volumes of low dose inside the patient body. Delivered dose could be the result of the cytotoxic injuries of the cells even away from the treatment field. We calculated the total dose absorbed in the patient body for four radiotherapy techniques to investigate whether some methods have a potential to reduce the exposure to the patient.

Materials and methods

We analyzed CyberKnife plans for 10 patients with localized prostate cancer. Five alternative plans for each patient were calculated with the VMAT, IMRT and TomoTherapy techniques. Alternative dose distributions were calculated to achieve the same coverage for PTV. Integral Dose formula was used to calculate the total dose delivered to the PTV and whole patient body.

Results

Analysis showed that the same amount of dose was deposited to the treated volume despite different methods of treatment delivery. The mean values of total dose delivered to the whole patient body differed significantly for each treatment technique. The highest integral dose in the patient's body was at the TomoTherapy and CyberKnife treatment session. VMAT was characterized by the lowest integral dose deposited in the patient body.

Conclusions

The highest total dose absorbed in normal tissue was observed with the use of a robotic radiosurgery system and TomoTherapy. These results demonstrate that the exposure of healthy tissue is a dosimetric factor which differentiates the dose delivery methods.

Abstract

Aim

Comparisons of integral dose delivered to the treatment planning volume and to the whole patient body during stereotactic, helical and intensity modulated radiotherapy of prostate.

Background

Multifield techniques produce large volumes of low dose inside the patient body. Delivered dose could be the result of the cytotoxic injuries of the cells even away from the treatment field. We calculated the total dose absorbed in the patient body for four radiotherapy techniques to investigate whether some methods have a potential to reduce the exposure to the patient.

Materials and methods

We analyzed CyberKnife plans for 10 patients with localized prostate cancer. Five alternative plans for each patient were calculated with the VMAT, IMRT and TomoTherapy techniques. Alternative dose distributions were calculated to achieve the same coverage for PTV. Integral Dose formula was used to calculate the total dose delivered to the PTV and whole patient body.

Results

Analysis showed that the same amount of dose was deposited to the treated volume despite different methods of treatment delivery. The mean values of total dose delivered to the whole patient body differed significantly for each treatment technique. The highest integral dose in the patient's body was at the TomoTherapy and CyberKnife treatment session. VMAT was characterized by the lowest integral dose deposited in the patient body.

Conclusions

The highest total dose absorbed in normal tissue was observed with the use of a robotic radiosurgery system and TomoTherapy. These results demonstrate that the exposure of healthy tissue is a dosimetric factor which differentiates the dose delivery methods.

Get Citation

Keywords

Prostate cancer; Integral dose; CyberKnife; VMAT; TomoTherapy

About this article
Title

Integral dose: Comparison between four techniques for prostate radiotherapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 20, No 2 (2015)

Pages

99-103

Published online

2015-03-01

DOI

10.1016/j.rpor.2014.10.010

Bibliographic record

Rep Pract Oncol Radiother 2015;20(2):99-103.

Keywords

Prostate cancer
Integral dose
CyberKnife
VMAT
TomoTherapy

Authors

Krzysztof Ślosarek
Wojciech Osewski
Aleksandra Grządziel
Michał Radwan
Łukasz Dolla
Marta Szlag
Małgorzata Stąpór-Fudzińska

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