open access

Vol 20, No 2 (2015)
Reviews
Published online: 2015-03-01
Submitted: 2014-10-30
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Silk as an innovative biomaterial for cancer therapy

Katarzyna Jastrzebska, Kamil Kucharczyk, Anna Florczak, Ewelina Dondajewska, Andrzej Mackiewicz, Hanna Dams-Kozlowska
DOI: 10.1016/j.rpor.2014.11.010
·
Rep Pract Oncol Radiother 2015;20(2):87-98.

open access

Vol 20, No 2 (2015)
Reviews
Published online: 2015-03-01
Submitted: 2014-10-30

Abstract

Silk has been used for centuries in the textile industry and as surgical sutures. In addition to its unique mechanical properties, silk possesses other properties, such as biocompatibility, biodegradability and ability to self-assemble, which make it an interesting material for biomedical applications. Although silk forms only fibers in nature, synthetic techniques can be used to control the processing of silk into different morphologies, such as scaffolds, films, hydrogels, microcapsules, and micro- and nanospheres. Moreover, the biotechnological production of silk proteins broadens the potential applications of silk. Synthetic silk genes have been designed. Genetic engineering enables modification of silk properties or the construction of a hybrid silk. Bioengineered hybrid silks consist of a silk sequence that self-assembles into the desired morphological structure and the sequence of a polypeptide that confers a function to the silk biomaterial. The functional domains can comprise binding sites for receptors, enzymes, drugs, metals or sugars, among others. Here, we review the current status of potential applications of silk biomaterials in the field of oncology with a focus on the generation of implantable, injectable and targeted drug delivery systems and the three-dimensional cancer models based on silk scaffolds for cancer research. However, the systems described could be applied in many biomedical fields.

Abstract

Silk has been used for centuries in the textile industry and as surgical sutures. In addition to its unique mechanical properties, silk possesses other properties, such as biocompatibility, biodegradability and ability to self-assemble, which make it an interesting material for biomedical applications. Although silk forms only fibers in nature, synthetic techniques can be used to control the processing of silk into different morphologies, such as scaffolds, films, hydrogels, microcapsules, and micro- and nanospheres. Moreover, the biotechnological production of silk proteins broadens the potential applications of silk. Synthetic silk genes have been designed. Genetic engineering enables modification of silk properties or the construction of a hybrid silk. Bioengineered hybrid silks consist of a silk sequence that self-assembles into the desired morphological structure and the sequence of a polypeptide that confers a function to the silk biomaterial. The functional domains can comprise binding sites for receptors, enzymes, drugs, metals or sugars, among others. Here, we review the current status of potential applications of silk biomaterials in the field of oncology with a focus on the generation of implantable, injectable and targeted drug delivery systems and the three-dimensional cancer models based on silk scaffolds for cancer research. However, the systems described could be applied in many biomedical fields.

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Keywords

Silkworm silk; Spider silk; Bioengineered silk; 3D cancer model; Cancer therapy; Drug delivery

About this article
Title

Silk as an innovative biomaterial for cancer therapy

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 20, No 2 (2015)

Pages

87-98

Published online

2015-03-01

DOI

10.1016/j.rpor.2014.11.010

Bibliographic record

Rep Pract Oncol Radiother 2015;20(2):87-98.

Keywords

Silkworm silk
Spider silk
Bioengineered silk
3D cancer model
Cancer therapy
Drug delivery

Authors

Katarzyna Jastrzebska
Kamil Kucharczyk
Anna Florczak
Ewelina Dondajewska
Andrzej Mackiewicz
Hanna Dams-Kozlowska

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