open access

Vol 19, No 5 (2014)
Original research articles
Published online: 2014-09-01
Submitted: 2012-06-28
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Nasopharyngeal carcinoma in dermatomyositis patients: A 10-year retrospective review in Hospital Selayang, Malaysia

J.W. Teoh, Razif M. Yunus, Faridah Hassan, Norazmi Ghazali, Zainal A.Z. Abidin
DOI: 10.1016/j.rpor.2014.02.005
·
Rep Pract Oncol Radiother 2014;19(5):332-336.

open access

Vol 19, No 5 (2014)
Original research articles
Published online: 2014-09-01
Submitted: 2012-06-28

Abstract

Aim

The objective of our review is to investigate the association between dermatomyositis patients and nasopharyngeal carcinoma (NPC) together with the clinical presentation of the patients and their management in otorhinolaryngology.

Background

NPC is a malignant disease with good prognosis on early diagnosis. However, the relationship between the dermatomyositis and NPC and its management is not well defined.

Materials and methods

A 10-year retrospective review of case records of 21 dermatomyositis patients seen in Otorhinolaryngology Department of Hospital Selayang from January 2000 to November 2010.

Results

These patients ranged from 19 to 74 years old and a total of 8 (38%) out of 21 adults with dermatomyositis were detected to have malignancy. Five out of 8 patients had NPC (62.5%). The mean age of patients with NPC and dermatomyositis was 48 years. NPC is diagnosed in 4 out of 5 patients (80%) in the first year of diagnosis of dermatomyositis. The clinical findings of the examination of nasopharynx ranged from hyperemia to exophytic nasopharyngeal mass. Histologically, it is only related to NPC of WHO types II and III.

Conclusions

There is a strong relationship between dermatomyositis and malignancy, especially NPC. Clinicians should have a high index of suspicion for malignancy in all dermatomyositis patients. Rigid nasoendoscopies and biopsies, serum Epstein–Barr viral capsid IgA antibody and imaging studies are helpful in detecting NPC in dermatomyositis patients.

Abstract

Aim

The objective of our review is to investigate the association between dermatomyositis patients and nasopharyngeal carcinoma (NPC) together with the clinical presentation of the patients and their management in otorhinolaryngology.

Background

NPC is a malignant disease with good prognosis on early diagnosis. However, the relationship between the dermatomyositis and NPC and its management is not well defined.

Materials and methods

A 10-year retrospective review of case records of 21 dermatomyositis patients seen in Otorhinolaryngology Department of Hospital Selayang from January 2000 to November 2010.

Results

These patients ranged from 19 to 74 years old and a total of 8 (38%) out of 21 adults with dermatomyositis were detected to have malignancy. Five out of 8 patients had NPC (62.5%). The mean age of patients with NPC and dermatomyositis was 48 years. NPC is diagnosed in 4 out of 5 patients (80%) in the first year of diagnosis of dermatomyositis. The clinical findings of the examination of nasopharynx ranged from hyperemia to exophytic nasopharyngeal mass. Histologically, it is only related to NPC of WHO types II and III.

Conclusions

There is a strong relationship between dermatomyositis and malignancy, especially NPC. Clinicians should have a high index of suspicion for malignancy in all dermatomyositis patients. Rigid nasoendoscopies and biopsies, serum Epstein–Barr viral capsid IgA antibody and imaging studies are helpful in detecting NPC in dermatomyositis patients.

Get Citation

Keywords

Dermatomyositis; Nasopharyngeal carcinoma; Epstein–Barr viral capsid IgA; WHO histology; Paraneoplastic

About this article
Title

Nasopharyngeal carcinoma in dermatomyositis patients: A 10-year retrospective review in Hospital Selayang, Malaysia

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 5 (2014)

Pages

332-336

Published online

2014-09-01

DOI

10.1016/j.rpor.2014.02.005

Bibliographic record

Rep Pract Oncol Radiother 2014;19(5):332-336.

Keywords

Dermatomyositis
Nasopharyngeal carcinoma
Epstein–Barr viral capsid IgA
WHO histology
Paraneoplastic

Authors

J.W. Teoh
Razif M. Yunus
Faridah Hassan
Norazmi Ghazali
Zainal A.Z. Abidin

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