open access

Vol 19, No 5 (2014)
Original research articles
Published online: 2014-09-01
Submitted: 2013-09-17
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Radiation-induced breast cancer in women with Hodgkin's disease

Elena Aleksandrova, Iglika Mihaylova, Sonya Sergieva, Vesselina Parvanova, Doroteya Ivanova
DOI: 10.1016/j.rpor.2014.01.003
·
Rep Pract Oncol Radiother 2014;19(5):317-321.

open access

Vol 19, No 5 (2014)
Original research articles
Published online: 2014-09-01
Submitted: 2013-09-17

Abstract

Aim and background

The aim of this study is to analyze the main clinical and pathologic characteristics of radiation-induced breast carcinomas (BC) following treatment for Hodgkin's disease (HD) and to identify the risk factors for their induction. To create a mathematical model for the prediction of expected age at which a BC might develop based on the age at treatment for HD.

Materials and methods

Thirty-nine cases of women with BC that developed after treatment for HD in puberty or adolescence were analyzed retrospectively. The median age at initiation of treatment for HD was 12.9 years (9–21). The median age at diagnosis of the second malignancy – breast carcinoma was 32.4 years (22.9–39).

Results

The distribution of patients according to the clinical T stage of breast cancer was as follows: 11 patients with T1 stage BC (28%), 22 with T2 stage (56%) and 6 with stage T3 (16%). Prevalent were tumors localized in the lateral breast quadrants. The observed 5 year survival was 95%.

Conclusion

The risk of solid tumors, especially breast cancer, is high among women with HD disease who were treated with radiotherapy in their childhood. In this article, we propose a specific mathematical age formula which could be used as predictive equation when the age of the treatment for HD is in the range between 9 and 21 years. Systematic screening for breast cancer in these patients would be significantly important for their health and could improve their survival.

Abstract

Aim and background

The aim of this study is to analyze the main clinical and pathologic characteristics of radiation-induced breast carcinomas (BC) following treatment for Hodgkin's disease (HD) and to identify the risk factors for their induction. To create a mathematical model for the prediction of expected age at which a BC might develop based on the age at treatment for HD.

Materials and methods

Thirty-nine cases of women with BC that developed after treatment for HD in puberty or adolescence were analyzed retrospectively. The median age at initiation of treatment for HD was 12.9 years (9–21). The median age at diagnosis of the second malignancy – breast carcinoma was 32.4 years (22.9–39).

Results

The distribution of patients according to the clinical T stage of breast cancer was as follows: 11 patients with T1 stage BC (28%), 22 with T2 stage (56%) and 6 with stage T3 (16%). Prevalent were tumors localized in the lateral breast quadrants. The observed 5 year survival was 95%.

Conclusion

The risk of solid tumors, especially breast cancer, is high among women with HD disease who were treated with radiotherapy in their childhood. In this article, we propose a specific mathematical age formula which could be used as predictive equation when the age of the treatment for HD is in the range between 9 and 21 years. Systematic screening for breast cancer in these patients would be significantly important for their health and could improve their survival.

Get Citation

Keywords

Breast cancer; Hodgkin' s disease; Risk factors

About this article
Title

Radiation-induced breast cancer in women with Hodgkin's disease

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 19, No 5 (2014)

Pages

317-321

Published online

2014-09-01

DOI

10.1016/j.rpor.2014.01.003

Bibliographic record

Rep Pract Oncol Radiother 2014;19(5):317-321.

Keywords

Breast cancer
Hodgkin's disease
Risk factors

Authors

Elena Aleksandrova
Iglika Mihaylova
Sonya Sergieva
Vesselina Parvanova
Doroteya Ivanova

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